skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Barrett Esophagus (CUI C0004763) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0004763

NCI Thesaurus Code: C2891  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)

RADLEX Definition: A condition with damage to the lining of the lower esophagus resulting from chronic acid reflux (esophagitis, reflux). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the intestine or the salmon-pink mucosa of the stomach. Barrett's columnar epithelium is a marker for severe reflux and precursor to adenocarcinoma of the esophagus. [MeSH]

GARD Definition: 

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

- this information is from GARD/ORDR/NCATS.

HPO Definition: An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system. [HPO:sdoelken]

NCI-GLOSS Definition: A condition in which the cells lining the lower part of the esophagus have changed or been replaced with abnormal cells that could lead to cancer of the esophagus. The backing up of stomach contents (reflux) may irritate the esophagus and, over time, cause Barrett's esophagus.

CSP Definition: syndrome including peptic ulcer of the lower esophagus, often with stricture, due to the presence of columnar lined epithelium, which may contain functional mucous cells, parietal cells, or chief cells in the esophagus instead of normal squamous cell epithelium; sometimes pre-malignant, followed by esophageal adenocarcinoma.

MSH Definition: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.

Synonyms & Abbreviations: (see Synonym Details)
Barret syndrome
Barrett Ösophagus
Barrett Esophagus [Disease/Finding]
Barrett esophagus
Barrett Metaplasia
Barrett syndrome
Barrett's disease
Barrett's Esophagitis
Barrett's esophagus (diagnosis)
Barrett's esophagus (disorder)
Barrett's esophagus NOS
BARRETT'S ESOPHAGUS
Barrett's oesophagitis
Barrett's oesophagus
Barrett's syndrome
Barretts esophagus
Barretts syndrome
BE
BO - Barrett's oesophagus
CELLO - Columnar epithelial-lined lower esophagus
CELLO - Columnar epithelial-lined lower oesophagus
CELLO
CLE - Columnar-lined esophagus
CLE - Columnar-lined oesophagus
CLE
Columnar Epithelial-Lined Lower Esophagus
Columnar epithelial-lined lower oesophagus
columnar epithelium lined lower esophagus
columnar epithelium lined lower oesophagus
Columnar-Lined Esophagus
Columnar-lined oesophagus
Endobrachyesophagus
Endobrachyoesophagus
Endobrachyooesophagus
Esophagus, Barrett's
ESOPHAGUS, BARRETT
ESOPHAGUS, COLUMNAR-LINED
Gastric metaplasia of esophagus
Gastric metaplasia of oesophagus
Syndrome, Barrett's
Syndrome, Barrett

External Source Codes: 
NCI Thesaurus Code C2891 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN note category; do not coord with INFANT, NEWBORN, DISEASES MSH
ANSWER_CODE 18 LNC
AQL BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source CTRP NCI
CTV3ID Xa9Bz SNOMEDCT_US
DATE_CREATED 2010-12-27T01:33:00Z HPO
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2006-07-23 PDQ
DATE_LAST_MODIFIED 2010-01-27 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 5000-0039 CSP
DISEASE_IDENTIFIER_ID 70 GARD
DX 19890101 MSH
EFFECTIVE_TIME 20150731 SNOMEDCT_US
EXCLUDES1 Barrett's ulcer (K22.1) ICD10CM
EXCLUDES1 malignant neoplasm of esophagus (C15.-) ICD10CM
EXTERNALLY_DEFINED N LNC
GENELOCUS ,1,0,q,2,2,.,1, OMIM
GENESYMBOL ASCC1 OMIM
GENESYMBOL p50 OMIM
GENESYMBOL SMABF2 OMIM
HAS_GARD_PAGE true GARD
HN 89(81); was see under ESOPHAGEAL DISEASES 1981-88 MSH
HPO_COMMENT The medical significance of Barrett esophagus is its strong association with esophageal adenocarcinoma, a particularly lethal cancer. HPO
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Barrett's: disease ICD10
INCLUSION_TERM Barrett's: syndrome ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19800404 MSH
MESH_DEFINITION A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus. NDFRT
MESH_DUI D001471 NDFRT
MESH_NAME Barrett Esophagus NDFRT
MESH_UI M0002186 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20130708 MSH
MN C06.198.102 MSH
MN C06.405.117.102 MSH
MSC Diagnosis.Term MTHMST
MSC Finding.Term MTHMST
NCI_THESAURUS_CODE C2891 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000000531 NDFRT
ORDER_NO 13062 ICD10CM
ORIG_STY Disease/diagnosis PDQ
PM 89; was see under ESOPHAGEAL DISEASES 1981-88 MSH
PRIMARY_PATH 10004137$10052778$10017943$10017947$Barrett's oesophagus$Gastrointestinal mucosal dystrophies and secretion disorders$Gastrointestinal conditions NEC$Gastrointestinal disorders MDR
PRIMARY_SOC 10017947 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/20/barrett-syndrome/resources/1 GARD
REF orcid.org/0000-0001-5208-3432 HPO
RXAUI 3116628 RXNORM
RXAUI 3116629 RXNORM
RXAUI 3116630 RXNORM
RXAUI 3116631 RXNORM
RXAUI 3116632 RXNORM
RXAUI 3155510 RXNORM
RXAUI 5930358 RXNORM
RXCUI 1022085 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 15.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_LMVERSION 15.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 196609006 NDFRT
SNOMED_CID 235597001 NDFRT
SNOMED_CID 302914006 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS K22.7 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~K22.7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K22.70 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BARRETT'S ESOPHAGUS WITH ESOPHAGITIS CHOOSE K20.9 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BARRETTS ESOPHAGUS WITH DYSPLASIA CHOOSE K22.719 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BARRETTS ESOPHAGUS WITH HIGH GRADE DYSPLASIA CHOOSE K22.711 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BARRETTS ESOPHAGUS WITH LOW GRADE DYSPLASIA CHOOSE K22.710 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 1082751000119109 | Barretts esophagus with dysplasia | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 1082761000119106 | Barretts esophagus with high grade dysplasia | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 1082771000119100 | Barretts esophagus with low grade dysplasia | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 235597001 | Barrett's esophagus with esophagitis | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K20.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K22.70 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K22.710 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K22.711 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K22.719 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Xa9Bz SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T004269 MSH
TERMUI T004270 MSH
TERMUI T004271 MSH
TERMUI T004272 MSH
TERMUI T004273 MSH
TERMUI T808123 MSH
TH NLM (1981) MSH
TH NLM (1999) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0004763

Mainbox Bottom