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Atherosclerosis (CUI C0004153) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0004153

NCI Thesaurus Code: C35768  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.

HPO Definition: A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow. [HPO:probinson]

MEDLINEPLUS Definition: 

Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body.

Atherosclerosis can lead to serious problems, including

  • Coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack.
  • Carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke.
  • Peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections.

Atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have it until they have a medical emergency.

A physical exam, imaging, and other diagnostic tests can tell if you have it. Medicines can slow the progress of plaque buildup. Your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress.

NIH: National Heart, Lung, and Blood Institute

CSP Definition: age, lifestyle, diet, and gene related degeneration of arteries due to deposition of lipoid plaques (atheromas) on inner arterial walls; main cause of coronary artery disease, a leading cause of death.

MSH Definition: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.

Synonyms & Abbreviations: (see Synonym Details)
arteriosclerotic vascular disease
ASVD
Atheromatosis
Atheroscleroses
Atherosclerosis (morphologic abnormality)
Atherosclerosis [Disease/Finding]
atherosclerosis
Atherosclerotic cardiovascular disease, so described
Atherosclerotic cardiovascular disease
ATHEROSCLEROTIC VASCULAR DISEASE

External Source Codes: 
NCI Thesaurus Code C35768 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source FDA NCI
CTV3ID XUD2I SNOMEDCT_US
DATE_CREATED 04/12/2010 MEDLINEPLUS
DATE_LAST_MODIFIED 10/09/2014 RADLEX
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0571-2508 CSP
DX 20060101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES2 arteriosclerotic cardiovascular disease (I25.1-) ICD10CM
EXCLUDES2 arteriosclerotic heart disease (I25.1-) ICD10CM
EXCLUDES2 atheroembolism (I75.-) ICD10CM
EXCLUDES2 cerebral atherosclerosis (I67.2) ICD10CM
EXCLUDES2 coronary atherosclerosis (I25.1-) ICD10CM
EXCLUDES2 mesenteric atherosclerosis (K55.1) ICD10CM
EXCLUDES2 precerebral atherosclerosis (I67.2) ICD10CM
EXCLUDES2 primary pulmonary atherosclerosis (I27.0) ICD10CM
FDA_Table Patient Code (Appendix B) NCI
FX D053298 MSH
FX D058226 MSH
HN 2006; use ARTERIOSCLEROSIS 1963-2005 MSH
HPO_COMMENT Strictly speaking, atherosclerosis is a specific type of arteriosclerosis ('hardening of the arteries'), although the terms are sometimes used interchangeably in clinical jargon. HPO
IAN DEFAULT ICD10
INCLUSION_TERM arteriolosclerosis ICD10
INCLUSION_TERM arteriosclerosis ICD10
INCLUSION_TERM arteriosclerotic vascular disease ICD10
INCLUSION_TERM atheroma ICD10
INCLUSION_TERM degeneration: arterial ICD10
INCLUSION_TERM degeneration: arteriovascular ICD10
INCLUSION_TERM degeneration: vascular ICD10
INCLUSION_TERM endarteritis deformans or obliterans ICD10
INCLUSION_TERM senile: arteritis ICD10
INCLUSION_TERM senile: endarteritis ICD10
LAST_CHANGES_TO_CLASS syn RADLEX
MDA 20050630 MSH
MESH_DEFINITION A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. NDFRT
MESH_DUI D050197 NDFRT
MESH_NAME Atherosclerosis NDFRT
MESH_UI M0001903 NDFRT
MMR 20100625 MSH
MN C14.907.137.126.307 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/atherosclerosis.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/atherosclerosis.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000171661 NDFRT
ORDER_NO 11529 ICD10CM
PM 2006; see ARTERIOSCLEROSIS 1963-2005 MSH
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
REF http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972?utm_source=google&utm_medium=abstract&utm_content=atherosclerosis&utm_campaign=knowledge-panel, orcid.org/0000-0001-5208-3432 HPO
RXAUI 3112196 RXNORM
RXAUI 3112197 RXNORM
RXCUI 1023749 RXNORM
SNOMED_CID 38716007 NDFRT
SOS A condition in which deposition of materials, often fat droplets, in the walls of arteries leads to narrowing and hardening of the arteries. AOD
SOS Excludes: atherosclerosis of bypass graft of the extremities (440.30-440.32); atheroembolism (445.01-445.89) ICD9CM
SOS Includes: arteriolosclerosis; arteriosclerosis (obliterans) (senile); arteriosclerotic vascular disease; atheroma; degeneration: {arterial; arteriovascular; vascular; endarteritis deformans or obliterans}; senile: {arteritis; endarteritis} ICD9CM
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUD2I SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T003768 MSH
TH NLM (1963) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code to identify: ICD10CM
USE_ADDITIONAL exposure to environmental tobacco smoke (Z77.22) ICD10CM
USE_ADDITIONAL history of tobacco dependence (Z87.891) ICD10CM
USE_ADDITIONAL occupational exposure to environmental tobacco smoke (Z57.31) ICD10CM
USE_ADDITIONAL tobacco dependence (F17.-) ICD10CM
USE_ADDITIONAL tobacco use (Z72.0) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0004153

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