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Aspirin (CUI C0004057) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0004057

NCI Thesaurus Code: C287  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: An orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties.

PDQ Definition: An orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention.

CSP Definition: prototypical analgesic used in the treatment of mild to moderate pain; has antiinflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins; aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.

MSH Definition: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Synonyms & Abbreviations: (see Synonym Details)
2-(ACETYLOXY)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoic acid
406186
50-78-2
acetylsalicylic acid
Acetylsalicylsaeure
Acid, Acetylsalicylic
Acide 2-(acetyloxy)benzoique
Acide acétylsalicylique
Acidum acetylsalicylicum
ASA
Aspergum
aspirin
Aspirin (product)
Aspirin (substance)
Aspirin [Chemical/Ingredient]
Azetylsalizylsaeure
Azetylsalizylsäure
Benzoic acid, 2-(acetyloxy)-
Ecotrin
Empirin
Entericin
Extren
Measurin
o-acetoxybenzoic acid
O-acetylsalicylic acid
o-carboxyphenyl acetate
Salicylic acid acetate
ácido acetilsalicílico

External Source Codes: 
NCI Thesaurus Code C287 (see NCI Thesaurus info)
CAS Registry Number 50-78-2 (see NLM ChemIDplus info)
FDA UNII Code R16CO5Y76E
NSC Code 406186 (see NCI DTP info)
PDQ Closed Trial Search ID 39152
PDQ Open Trial Search ID 39152 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Mild to moderate pain; fever; prevention of arterial and venous thrombosis NCI
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15365 NCI
Chemical_Formula C9H8O4 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID x02LX SNOMEDCT_US
CTV3ID XUWwh SNOMEDCT_US
DATE_LAST_MODIFIED 2015-10-06 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2270-2387 CSP
DX 19650101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE R16CO5Y76E DRUGBANK
FDA_UNII_CODE R16CO5Y76E NDFRT
HN 65; was ACETYLSALICYLIC ACID 1963-64 MSH
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) NDFRT
MESH_DUI D001241 NDFRT
MESH_NAME Aspirin NDFRT
MESH_UI M0001864 NDFRT
MMR 20130708 MSH
MN D02.455.426.559.389.657.410.595.176 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C287 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006582 NDFRT
NUI N0000145918 NDFRT
ORIG_STY Drug/agent PDQ
PA D000894 MSH
PA D005343 MSH
PA D010975 MSH
PA D016861 MSH
PA D058633 MSH
PID 1772 PDQ
PM 65; was ACETYLSALICYLIC ACID 1963-64 MSH
RN 0 MSH
RN R16CO5Y76E MSH
RR 50-78-2 (Aspirin) MSH
RXAUI 1136086 RXNORM
RXAUI 1136089 RXNORM
RXAUI 1136097 RXNORM
RXAUI 2067937 RXNORM
RXAUI 2596464 RXNORM
RXAUI 2598363 RXNORM
RXAUI 2621231 RXNORM
RXAUI 3092405 RXNORM
RXAUI 3102962 RXNORM
RXAUI 3102963 RXNORM
RXAUI 3104973 RXNORM
RXAUI 3112009 RXNORM
RXAUI 3112010 RXNORM
RXAUI 3117281 RXNORM
RXAUI 38593 RXNORM
RXCUI 1191 RXNORM
RXCUI 202546 RXNORM
RXCUI 202547 RXNORM
RXCUI 202554 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
SID APRD00264 DRUGBANK
SID EXPT00475 DRUGBANK
SNOMEDID C-60320 SNOMEDCT_US
SNOMEDID F-61BB8 SNOMEDCT_US
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SPL_SET_ID f1fe57c7-a7ea-450d-b9b9-39d512b31d79 MTHSPL
SPL_SET_ID f2a263f8-7d91-48c2-a27a-45c208b7bf44 MTHSPL
SPL_SET_ID f2e7332a-bcd6-4aef-9e4c-a2cef5ea9464 MTHSPL
SPL_SET_ID f2f9b930-7b54-46c5-8631-d673a52a9eb4 MTHSPL
SPL_SET_ID f34adff8-a823-4a00-a211-3d65e742639c MTHSPL
SPL_SET_ID f39ef03e-1df7-4710-b23f-c929e80fa705 MTHSPL
SPL_SET_ID f414b76d-22e6-4874-b889-bb8ddc76ac7b MTHSPL
SPL_SET_ID f43685f0-d7f4-40b9-9de4-1ee272e7b085 MTHSPL
SPL_SET_ID f49d3755-bb1b-4b79-baa5-52ad16b2ea64 MTHSPL
SPL_SET_ID f4aa0de9-ffcc-4140-91a3-fd9e7a55f2ac MTHSPL
SPL_SET_ID f504985c-f11a-4959-8d33-445bc154752f MTHSPL
SPL_SET_ID f517ce40-b4fa-4d03-a568-b3c23e1cfbd4 MTHSPL
SPL_SET_ID f572d9fe-035b-4c23-93a2-c7672261066e MTHSPL
SPL_SET_ID f5927ffb-e586-4fec-8e76-8fd371330b52 MTHSPL
SPL_SET_ID f6a9ea44-08b8-4a33-bfbd-68cb2d852c39 MTHSPL
SPL_SET_ID f786e564-1d03-4c10-8e89-f406f015f607 MTHSPL
SPL_SET_ID f7ca9f4a-f8ef-46d2-9536-b69541e6653d MTHSPL
SPL_SET_ID f7d3be7a-09b6-45d4-aad7-cb07d7de6f98 MTHSPL
SPL_SET_ID f7e270a2-7578-4da2-87b6-325df9c90be8 MTHSPL
SPL_SET_ID f815feab-5e8c-40a9-b241-1ac1c0ffa50d MTHSPL
SPL_SET_ID f82a3ca9-e2fd-4797-a881-4b9bc68ab093 MTHSPL
SPL_SET_ID f8c8b776-1ec2-4ba6-8a5f-f12a0b47d09e MTHSPL
SPL_SET_ID f950d4eb-39b9-4ef7-b5f3-0cf45d4d6bc0 MTHSPL
SPL_SET_ID f962c0fa-a4a9-444d-9f11-86c19c8368f3 MTHSPL
SPL_SET_ID fa14aff4-2286-42c6-ab2c-054d2b1a188e MTHSPL
SPL_SET_ID fa23be25-61c3-491c-b9e6-a5275c9bdc13 MTHSPL
SPL_SET_ID fb13ff24-0602-421b-9c94-ce1e04bb97c1 MTHSPL
SPL_SET_ID fb6bca25-8d03-4fa5-a3a8-e595fe089a22 MTHSPL
SPL_SET_ID fb75f688-5a6e-4299-90c6-23d2f8c91532 MTHSPL
SPL_SET_ID fbd2a03f-c9cd-4b0d-b9b1-aaa3bc14efb4 MTHSPL
SPL_SET_ID fbdd8197-60f3-4b48-9f36-809beed873c1 MTHSPL
SPL_SET_ID fbe278a7-f6dc-4103-a71f-9de346044bf1 MTHSPL
SPL_SET_ID fbe8ddc3-1016-4826-98e8-cea34c752cc2 MTHSPL
SPL_SET_ID fbfa46b6-1773-4053-b323-66f4321d6472 MTHSPL
SPL_SET_ID fcfa0feb-f499-44c2-adc3-86e0dceb3016 MTHSPL
SPL_SET_ID fd256c4a-a176-45dc-b757-fc01eb105008 MTHSPL
SPL_SET_ID fd3cda41-e095-4811-8918-44356f1275f9 MTHSPL
SPL_SET_ID fdc3cb8c-2d8d-404e-9ba1-d030c8f5675d MTHSPL
SPL_SET_ID fe12519c-3e5f-4592-bd34-2d6b81b981f4 MTHSPL
SPL_SET_ID fe187777-b0de-4afb-80be-5b2ff7141a69 MTHSPL
SPL_SET_ID fe898970-a9ee-4e79-bdb9-7457753e857d MTHSPL
SPL_SET_ID fe94e772-8bf4-4225-8cff-285bfa8e5828 MTHSPL
SPL_SET_ID fee1f9cd-7234-4e02-afae-1386af6a4775 MTHSPL
SPL_SET_ID ff57b70f-6f38-441c-943b-937730ba188c MTHSPL
SPL_SET_ID ffa679f4-04d2-4aac-84df-2b99d08ca25d MTHSPL
SPL_SET_ID ffc99783-2cf5-4228-a98c-1b873eea3790 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x02LX SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWwh SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-60320 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-61BB8 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T003712 MSH
TERMUI T003713 MSH
TERMUI T003714 MSH
TERMUI T003724 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH JAN (19XX) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^129^Active/Master NDFRT
VANDF_RECORD 50.6^964^Active/Master NDFRT
VUID 4017536 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0004057

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