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Aortic Valve Stenosis (CUI C0003507) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0003507

NCI Thesaurus Code: C50462  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Narrowing of the orifice of the aortic valve.

GARD Definition: Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. Individuals with severe cases may faint without warning. The condition can eventually lead to heart failure. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever. Treatment may include medications to ease the symptoms, but surgery to repair or replace the valve is the only way to eliminate the condition. - this information is from GARD/ORDR/NCATS.

HPO Definition: The presence of a stenosis (narrowing) of the aortic valve. [HPO:probinson]

FDA Definition: Narrowing of the orifice of the aortic valve or of the supravalvular or subvalvular regions.

CSP Definition: constriction in the opening of the aortic valve or of the supravalvular or subvalvular regions.

MSH Definition: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

Synonyms & Abbreviations: (see Synonym Details)
Aortic (valve) stenosis
AORTIC STENOSIS
Aortic Valve Stenoses
Aortic valve stenosis (disorder)
Aortic Valve Stenosis [Disease/Finding]
AORTIC VALVE STENOSIS
AORTIC VALVULAR STENOSIS
Narrowing of aortic valve
Stenosed aortic valve
Stenoses, Aortic Valve
Stenoses, Aortic
STENOSIS AORTIC VALVE
Stenosis of aorta
Stenosis of aortic valve
Stenosis, Aortic Valve
Stenosis, Aortic
Valve Stenoses, Aortic
Valve Stenosis, Aortic
Valvular aortic stenosis

External Source Codes: 
NCI Thesaurus Code C50462 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN aortic valve atresia = AORTIC VALVE /abnorm MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source FDA NCI
Contributing_Source NICHD NCI
CTV3ID X2011 SNOMEDCT_US
DATE_CREATED 2013-01-02T00:07:00 GARD
DATE_LAST_MODIFIED 2013-01-02T00:07:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 1393-3787 CSP
DISEASE_IDENTIFIER_ID 22835 GARD
DISEASE_IDENTIFIER_ID 22836 GARD
DX 19670101 MSH
EFFECTIVE_TIME 20050131 SNOMEDCT_US
FDA_Table Patient Code (Appendix B) NCI
FX D002312 MSH
HAS_GARD_PAGE true GARD
HN 67; was AORTIC STENOSIS 1963-66; AORTIC VALVE DISEASES was heading 1963-66 MSH
HPO_COMMENT Aortic stenosis can lead to a pressure gradient between the left ventricle and the aorta and may result in left ventricular hypertrophy and decreased left ventricular compliance. HPO
IAN DEFAULT ICD10
IDENTIFIER_ORDER 2 GARD
IDENTIFIER_ORDER 3 GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Supravalvular aortic stenosis ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Modified GARD
MDA 19990101 MSH
MESH_DEFINITION A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA. NDFRT
MESH_DUI D001024 NDFRT
MESH_NAME Aortic Valve Stenosis NDFRT
MESH_UI M0001557 NDFRT
MMR 20070709 MSH
MN C14.280.484.150 MSH
MN C14.280.955.249 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Aortic Valve Stenosis NCI
NUI N0000000445 NDFRT
OL use AORTIC VALVE STENOSIS to search AORTIC STENOSIS 1966; search AORTIC VALVE DISEASES under HEART VALVE DISEASES 1966 MSH
PM 67; was AORTIC STENOSIS 1963-66; AORTIC VALVE DISEASES was heading 1963-66 MSH
PRIMARY_PATH 10002906$10002901$10003216$10047065$Aortic stenosis$Aortic necrosis and vascular insufficiency$Arteriosclerosis, stenosis, vascular insufficiency and necrosis$Vascular disorders MDR
PRIMARY_PATH 10002918$10002911$10046973$10007541$Aortic valve stenosis$Aortic valvular disorders$Cardiac valve disorders$Cardiac disorders MDR
PRIMARY_SOC 10007541 MDR
PRIMARY_SOC 10047065 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5830/aortic-valve-stenosis/resources/1 GARD
REF orcid.org/0000-0001-5208-3432 HPO
RXAUI 3110729 RXNORM
RXAUI 3110745 RXNORM
RXAUI 3110746 RXNORM
RXCUI 1021926 RXNORM
SID HP:0005140 HPO
SNOMED_CID 60573004 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS I35.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~I35.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS I35.0 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I35.0 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X2011 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T003130 MSH
TERMUI T003131 MSH
TH NLM (1967) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0003507

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