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Antidepressive Agents (CUI C0003289) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0003289

NCI Thesaurus Code: C265  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

NCIt Definition: A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression.

MEDLINEPLUS Definition: 

Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They work to balance some of the natural chemicals in our brains. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try a few before finding what works best for you.

Antidepressants may cause mild side effects that usually do not last long. These may include headache, nausea, sleep problems, restlessness, and sexual problems. Tell your doctor if you have any side effects. You should also let your doctor know if you take any other medicines, vitamins, or herbal supplements.

It is important to keep taking your medicines, even if you feel better. Do not stop taking your medicines without talking to your doctor. You often need to stop antidepressants gradually.

NIH: National Institute of Mental Health

NCI-GLOSS Definition: A drug used to treat depression.

CSP Definition: mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.

MSH Definition: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

Synonyms & Abbreviations: (see Synonym Details)
[CN600] ANTIDEPRESSANTS
Agents, Antidepressive
Antidepressant (product)
Antidepressant (substance)
Antidepressant Agent
Antidepressant Drugs
antidepressants
antidepressant
Antidepressive Agent [TC]
antidepressive agents
Antidepressive Agent
Antidepressive
Drugs, Antidepressant

External Source Codes: 
NCI Thesaurus Code C265 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN GEN or unspecified; prefer specific groups or specific antidepressive agents; consider also DEPRESSION /drug ther MSH
AQL AD AE AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHEBI_ID CHEBI:35469 NCI
CONCEPT_TYPE TC MED-RT
CTV3ID x000f SNOMEDCT_US
CTV3ID XUVzg SNOMEDCT_US
DATE_CREATED 03/21/2005 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2484-5534 CSP
DRUG_CLASS_TYPE 1 VANDF
DX 19660101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20060731 SNOMEDCT_US
FX D008996 MSH
HN 66; PSYCHIC ENERGIZERS was see ANTIDEPRESSIVE AGENTS 1963-94; THYMOLEPTICS was see TRANQUILIZING AGENTS 1969-78 MSH
HN Changed descriptor 1995; through 1995 also use "antidepressive agents." AOD
LEVEL USP Category USPMG
LEVEL VA Class NDFRT
MDA 19990101 MSH
MMR 20140625 MSH
MN D27.505.954.427.700.122 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/antidepressants.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/antidepressants.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Mental Health http://www.nimh.nih.gov/ MEDLINEPLUS
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND THERAPEUTIC_CATEGORY_KIND NDFRT
NUI N0000029147 NDFRT
NUI N0000178314 NDFRT
OL use ANTIDEPRESSIVE AGENTS to search PSYCHIC ENERGIZERS 1966-94; use ANTIDEPRESSIVE AGENTS & TRANQUILIZING AGENTS to search THYMOLEPTICS 1969-78 MSH
PARENT_CLASS 69 VANDF
PM 66; PSYCHIC ENERGIZERS was see ANTIDEPRESSIVE AGENTS 1963-94; THYMOLEPTICS was see TRANQUILIZING AGENTS 1969-78 MSH
RN 0 MSH
RXAUI 2626800 RXNORM
RXAUI 3101682 RXNORM
RXAUI 3109867 RXNORM
RXAUI 3109868 RXNORM
RXAUI 3109869 RXNORM
RXAUI 3109870 RXNORM
RXAUI 3257581 RXNORM
RXCUI 927 RXNORM
SOS (RIS 27:202-11 entry; amitriptyline, RIS 27:199--3 entries; imipramine, RIS 27-210--1 entry) AOD
SOS A major classification of drugs that were developed recently, are sold only by prescription, and are used medically to improve mood in severely depressed patients. Generally divided into the tricyclic compounds amitriptyline hydrochloride and imipramine hydrochloride and the MAO inhibitors; rarely used for nonmedical purposes since they have little immediate pleasurable effect on normal mood states. This varied group of drugs seems to have a stimulant effect in cases of pathologic depression but appears to have little effect in normal states. Chronic usage, however, has been shown to have clearly defined stimulatory action. Although some of the stimulants have been medically used as antidepressants, their effects are inconsistent. AOD
SUBSET_MEMBER 900000000000497000~MAPTARGET~x000f SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVzg SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERM_STATUS A MED-RT
TERMUI T002758 MSH
TERMUI T002759 MSH
TERMUI T002760 MSH
TH NLM (1966) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VAC CN600 NDFRT
VAC CN600 VANDF
VANDF_RECORD 50.605^86^Active/Master NDFRT
VUID 4021594 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0003289

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