|Terms & Properties|
Concept Unique Identifier (CUI): C0003289
NCI Thesaurus Code: C265 (see NCI Thesaurus info)
Semantic Type: Pharmacologic Substance
NCIt Definition: A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression.
Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They work to balance some of the natural chemicals in our brains. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try a few before finding what works best for you.
Antidepressants may cause mild side effects that usually do not last long. These may include headache, nausea, sleep problems, restlessness, and sexual problems. Tell your doctor if you have any side effects. You should also let your doctor know if you take any other medicines, vitamins, or herbal supplements.
It is important to keep taking your medicines, even if you feel better. Do not stop taking your medicines without talking to your doctor. You often need to stop antidepressants gradually.
NIH: National Institute of Mental Health
NCI-GLOSS Definition: A drug used to treat depression.
CSP Definition: mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
MSH Definition: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Synonyms & Abbreviations: (see Synonym Details)
|Antidepressive Agent [TC]|
External Source Codes:
|NCI Thesaurus Code||C265 (see NCI Thesaurus info)|
|AN||GEN or unspecified; prefer specific groups or specific antidepressive agents; consider also DEPRESSION /drug ther||MSH|
|AQL||AD AE AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR||MSH|
|HN||66; PSYCHIC ENERGIZERS was see ANTIDEPRESSIVE AGENTS 1963-94; THYMOLEPTICS was see TRANQUILIZING AGENTS 1969-78||MSH|
|HN||Changed descriptor 1995; through 1995 also use "antidepressive agents."||AOD|
|MP_PRIMARY_INSTITUTE_URL||National Institute of Mental Health http://www.nimh.nih.gov/||MEDLINEPLUS|
|OL||use ANTIDEPRESSIVE AGENTS to search PSYCHIC ENERGIZERS 1966-94; use ANTIDEPRESSIVE AGENTS & TRANQUILIZING AGENTS to search THYMOLEPTICS 1969-78||MSH|
|PM||66; PSYCHIC ENERGIZERS was see ANTIDEPRESSIVE AGENTS 1963-94; THYMOLEPTICS was see TRANQUILIZING AGENTS 1969-78||MSH|
|SOS||(RIS 27:202-11 entry; amitriptyline, RIS 27:199--3 entries; imipramine, RIS 27-210--1 entry)||AOD|
|SOS||A major classification of drugs that were developed recently, are sold only by prescription, and are used medically to improve mood in severely depressed patients. Generally divided into the tricyclic compounds amitriptyline hydrochloride and imipramine hydrochloride and the MAO inhibitors; rarely used for nonmedical purposes since they have little immediate pleasurable effect on normal mood states. This varied group of drugs seems to have a stimulant effect in cases of pathologic depression but appears to have little effect in normal states. Chronic usage, however, has been shown to have clearly defined stimulatory action. Although some of the stimulants have been medically used as antidepressants, their effects are inconsistent.||AOD|
Additional Concept Data: (none)