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Anti-Inflammatory Agents, Non-Steroidal (CUI C0003211) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0003211

NCI Thesaurus Code: C257  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

NCIt Definition: A pharmacological agent that is not a steroid and has potential anti-inflammatory, analgesic, antipyretic and anti-platelet activities. Most nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the conversion of arachidonic acid to the precursors of prostaglandin and thromboxane by cyclooxygenase enzymes.

MSH Definition: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

NCI-GLOSS Definition: A group of drugs that decrease fever, swelling, pain, and redness.

NICHD Definition: A class of medication typically used for its analgesic, antipyretic, anti-inflammatory, and/or platelet-inhibitory effects. Effects are classically exerted through inhibition of cyclooxygenase 1 and/or cyclooxygenase 2, though other pharmacologic effects may be involved.

CSP Definition: agents that counteract or suppress inflammation and are not steroids; most have in addition analgesic, antipyretic, and platelet-inhibitory actions; they act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins: inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Synonyms & Abbreviations: (see Synonym Details)
Agents, Non-Steroidal Anti-Inflammatory
Agents, Nonsteroidal Anti-Inflammatory
Agents, Nonsteroidal Antiinflammatory
AIANS
ANTI INFLAMM AGENTS NONSTEROIDAL
Anti Inflammatory Agents, Non Steroidal
Anti Inflammatory Agents, Nonsteroidal
Anti-Inflammatory Agents, Non-Steroidal
Anti-Inflammatory Agents, Nonsteroidal
ANTIINFLAMM AGENTS NON STEROIDAL
ANTIINFLAMMATORY AGENTS NONSTEROIDAL
Antiinflammatory Agents, Non Steroidal
Antiinflammatory Agents, Nonsteroidal
NON STEROIDAL ANTI INFLAMM AGENTS
Non Steroidal Anti Inflammatory Agents
Non-steroidal anti-inflammatory agent (product)
Non-steroidal anti-inflammatory agent (substance)
Non-Steroidal Anti-Inflammatory Agents
Non-steroidal Anti-inflammatory Agent
Non-steroidal Anti-inflammatory Drug
Non-steroidal Antiinflammatory Agent
Non-steroidal Antiinflammatory Drug
Nonsteroidal Anti Inflammatory Agents
Nonsteroidal Anti-Inflammatory Agents
Nonsteroidal Anti-inflammatory Agent
Nonsteroidal Anti-inflammatory Drug [EPC]
nonsteroidal anti-inflammatory drugs
nonsteroidal anti-inflammatory drug
Nonsteroidal Antiinflammatory Agents
nonsteroidal antiinflammatory agent
Nonsteroidal antiinflammatory drugs
Nonsteroidal Antiinflammatory Drug
NSAIA
NSAID - Non-steroidal anti-inflammatory drug
NSAIDS
NSAID

External Source Codes: 
NCI Thesaurus Code C257 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Inflammation NCI
ACTIVE 1 SNOMEDCT_US
AQL AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:35475 NCI
Contributing_Source NICHD NCI
CTV3ID j2... SNOMEDCT_US
CTV3ID XUVyn SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 4007-0090 CSP
DX 19870101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
HN 87; ANALGESICS, ANTI-INFLAMMATORY was heading 1975-89 MSH
LEVEL USP Class USPMG
MDA 19860623 MSH
MMR 20130708 MSH
MN D27.505.696.663.850.014.040.500 MSH
MN D27.505.954.158.030 MSH
MN D27.505.954.329.030 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NICHD_Hierarchy_Term Nonsteroidal Antiinflammatory Drug NCI
NUI N0000175722 NDFRT
OL use ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL to search ANALGESICS, ANTI-INFLAMMATORY 1975-89 MSH
PM 87; ANALGESICS, ANTI-INFLAMMATORY was heading 1975-89 MSH
RN 0 MSH
RXAUI 3204005 RXNORM
RXAUI 3207398 RXNORM
RXAUI 3207400 RXNORM
RXAUI 3207401 RXNORM
RXAUI 3207403 RXNORM
RXAUI 3207502 RXNORM
RXAUI 3207505 RXNORM
RXAUI 3207506 RXNORM
RXAUI 3207507 RXNORM
RXAUI 3207509 RXNORM
RXCUI 1447076 RXNORM
SNOMED_CID 16403005 NDFRT
SNOMED_CID 372665008 NDFRT
SNOMEDID C-60300 SNOMEDCT_US
SNOMEDID F-61898 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~j2... SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVyn SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-60300 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-61898 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T002616 MSH
TERMUI T002617 MSH
TERMUI T002618 MSH
TERMUI T002619 MSH
TERMUI T002620 MSH
TERMUI T002621 MSH
TERMUI T002622 MSH
TH NLM (1987) MSH
TH NLM (1991) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0003211

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