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Angioedema (CUI C0002994) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002994

NCI Thesaurus Code: C112175  (see NCI Thesaurus info)

Semantic Type: Pathologic Function

NCIt Definition: Rapid swelling of the deep layers of the skin due to transient vascular leakage of serous fluid.

HPO Definition: Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis. [HPO:sdoelken]

NICHD Definition: Rapid swelling of the deep layers of the skin due to transient vascular leakage of serous fluid.

MSH Definition: Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.

Synonyms & Abbreviations: (see Synonym Details)
ANGIO-EDEMA
Angio-oedema-urticaria
Angio-oedema
Angioedema (disorder)
Angioedema [Disease/Finding]
Angioedema and urticaria
Angioedema-urticaria
Angioedemas
angioedema
Angioneurotic Edemas
Angioneurotic Edema
Angioneurotic oedema
Angiooedema
BANNISTER DISEASE
EDEMA ANGIONEUROTIC
EDEMA QUINCKE'S
Edema, Angioneurotic
EDEMA, CIRCUMSCRIBED
Edema, Quincke's
Edemas, Angioneurotic
GIANT HIVES
Giant urticaria (disorder)
Giant Urticarias
giant urticaria
HIVES GIANT
MILTON-QUINCKE GIANT URTICARIA
Oedema angioneurotic
Oedema Quincke's
Quincke edema
QUINCKE SYNDROME
Quincke's disease
Quincke's edema
Quincke's oedema
Quinckes Edema
URTICARIA GIANT
URTICARIA, GIANT
Urticaria-angio-oedema
Urticaria-angioedema
Urticarias, Giant

External Source Codes: 
NCI Thesaurus Code C112175 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /genet: consider also ANGIOEDEMAS, HEREDITARY MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID SN51. SNOMEDCT_US
CTV3ID XUZ09 SNOMEDCT_US
DATE_CREATED 2010-12-30T01:09:59Z HPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1849-1576 CSP
DID 2716-7007 CSP
DX 20080101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030731 SNOMEDCT_US
EXCLUDES1 serum urticaria (T80.6-) ICD10CM
EXCLUDES1 urticaria (L50.-) ICD10CM
HN 2008 (1963) MSH
HPO_COMMENT Apart from the common form, mediated by allergy, it has been reported as a side effect of some medications, in particular ACE inhibitors. Additionally, there are three autosomal dominant inherited forms known, due to mutations in the genes that control the clotting cascade, including the SERPING1 gene, which results in deficiency of the blood protein C1-inhibitor (type I HAE) and the F12 gene, which controls Factor XII (type III HAE). There is an additional type in which C1 levels are normal but C1 function is decreased (type II HAE). All three forms are called hereditary angioedema (HAE) or occasionally by the outdated term 'hereditary angioneurotic edema' (HANE). In all forms of HAE, swelling may also occur in the digestive tract and other organs. It is life-threatening when it involves the larynx due to the potential for asphyxiation. HPO
IAN DEFAULT ICD10
INCLUSION_TERM Giant urticaria ICD10
INCLUSION_TERM Quincke's oedema ICD10
MDA 19990101 MSH
MESH_DEFINITION Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx. NDFRT
MESH_DUI D000799 NDFRT
MESH_NAME Angioedema NDFRT
MESH_UI M0001197 NDFRT
MMR 20090706 MSH
MN C14.907.079 MSH
MN C17.800.862.945.066 MSH
MN C20.543.480.904.066 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Angioedema NCI
NUI N0000000415 NDFRT
ORDER_NO 80196 ICD10CM
PM 2008; see ANGIONEUROTIC EDEMA 1963-2007 MSH
PRIMARY_PATH 10002424$10002425$10002426$10040785$Angioedema$Angioedemas$Angioedema and urticaria$Skin and subcutaneous tissue disorders MDR
PRIMARY_SOC 10040785 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3227074 RXNORM
RXAUI 3253036 RXNORM
RXAUI 3286674 RXNORM
RXAUI 3286675 RXNORM
RXAUI 3286680 RXNORM
RXCUI 1022344 RXNORM
SID HP:0100666 HPO
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 16.0 MDR
SMQ_TERM_ADDVERSION 19.0 MDR
SMQ_TERM_ADDVERSION 8.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT B MDR
SMQ_TERM_CAT C MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.0 MDR
SMQ_TERM_LMVERSION 13.0 MDR
SMQ_TERM_LMVERSION 16.0 MDR
SMQ_TERM_LMVERSION 19.0 MDR
SMQ_TERM_LMVERSION 8.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 400075008 NDFRT
SNOMED_CID 41291007 NDFRT
SNOMEDID D0-20100 SNOMEDCT_US
SNOMEDID D0-2015F SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS T78.3 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~T78.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS T78.3XX? | DESCENDANTS NOT EXHAUSTIVELY MAPPED | EPISODE OF CARE INFORMATION NEEDED | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS T78.3XX? | EPISODE OF CARE INFORMATION NEEDED | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~T78.3XX? SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~SN51. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUZ09 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D0-20100 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D0-2015F SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T002368 MSH
TERMUI T002369 MSH
TERMUI T002370 MSH
TERMUI T002371 MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002994

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