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Pernicious Anemia (CUI C0002892) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002892

NCI Thesaurus Code: C2871  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Megaloblastic anemia caused by vitamin B-12 deficiency due to impaired absorption. The impaired absorption of vitamin B-12 is secondary to atrophic gastritis and loss of gastric parietal cells.

NCI-GLOSS Definition: A type of anemia (low red blood cell count) caused by the body's inability to absorb vitamin B12.

NICHD Definition: Megaloblastic anemia caused by vitamin B12 deficiency due to insufficient production of intrinsic factor by gastric parietal cells, which is essential for adequate absorption of vitamin B12. It is classically characterized by weakness and fatigue, glossitis, and paresthesias.

CSP Definition: anemia due to poor intestinal absorption of vitamin B12 caused by defective production of intrinsic factor (a carrier protein) by the gastric mucosa.

MSH Definition: A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)

Synonyms & Abbreviations: (see Synonym Details)
Addison anemia
Addison's anaemia
Addison's anemia
Addison-Biermer anaemia
Addison-Biermer anemia
Addisonian anaemia
Addisonian anemia
Addisonian pernicious anaemia
Addisonian pernicious anemia
Addisons Anemia
Anaemia pernicious type
Anaemia pernicious
ANEMIA PERNICIOUS TYPE
Anemia pernicious
Anemia, Addison's
ANEMIA, ADDISONIAN PERNICIOUS
Anemia, Addisons
Anemia, Addison
ANEMIA, BIERMER
Anemia, Pernicious [Disease/Finding]
ANEMIA, PERNICIOUS
Biermer anemia
Biermer's anaemia
Biermer's anemia
Intrinsic Factor Deficiency
malignant anemia
Megaloblastic anaemia due to impaired absorption of cobalamin
Megaloblastic anemia due to impaired absorption of cobalamin
PA - Pernicious anaemia
Pernicious anaemia NOS
Pernicious anaemia
Pernicious anemia (disorder)
Pernicious anemia NOS
pernicious anemia

External Source Codes: 
NCI Thesaurus Code C2871 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN a type of megaloblastic anemia MSH
ANSWER_CODE 5 LNC
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID XE2ro SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0427-3254 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FX D012546 MSH
ICE Anemia: {Addison's; Biermer's; congenital pernicious}; Congenital intrinsic factor [Castle's] deficiency ICD9CM
MDA 19990101 MSH
MESH_DEFINITION A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed) NDFRT
MESH_DUI D000752 NDFRT
MESH_NAME Anemia, Pernicious NDFRT
MESH_UI M0001137 NDFRT
MIMTYPE 0 OMIM
MIMTYPEMEANING Other, mainly phenotypes with suspected mendelian basis OMIM
MIMTYPEVALUE none OMIM
MMR 20120703 MSH
MN C15.378.071.252.196.500 MSH
MN C18.654.521.500.133.699.923.280 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Pernicious Anemia NCI
NUI N0000000396 NDFRT
PRIMARY_PATH 10034695$10002042$10002086$10005329$Pernicious anaemia$Anaemia deficiencies$Anaemias nonhaemolytic and marrow depression$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3106291 RXNORM
RXAUI 3108930 RXNORM
RXAUI 3108987 RXNORM
RXAUI 3108988 RXNORM
RXAUI 5039803 RXNORM
RXCUI 1023748 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 12.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_STATUS I MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 84027009 NDFRT
SOS Excludes: combined system disease without mention of anemia (266.2); subacute degeneration of spinal cord without mention of anemia (266.2) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D51.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D51.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D51.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BIERMER'S CONGENITAL PERNICIOUS ANEMIA CHOOSE D51.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MEGALOBLASTIC ANEMIA DUE TO DECREASED INTAKE OF VITAMIN B>12< CHOOSE D51.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MEGALOBLASTIC ANEMIA DUE TO DECREASED INTAKE OF VITAMIN B>12< CHOOSE D53.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SELECTIVE MALABSORPTION OF CYANOCOBALAMIN CHOOSE D51.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SELECTIVE MALABSORPTION OF CYANOCOBALAMIN CHOOSE D51.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 234362006 | Biermer's congenital pernicious anemia | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 234363001 | Selective malabsorption of cyanocobalamin | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 44910003 | Megaloblastic anemia due to decreased intake of vitamin B>12< | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D51.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D51.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D51.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D51.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D53.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XE2ro SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T002245 MSH
TERMUI T002246 MSH
TERMUI T002247 MSH
TERMUI T811413 MSH
TH NLM (1966) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002892

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