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Megaloblastic Anemia (CUI C0002888) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002888

NCI Thesaurus Code: C34382  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. It is usually caused by vitamin B12 or folic acid deficiency. Other causes include toxins and drugs.

HPO Definition: Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts). [HPO:probinson]

NICHD Definition: A disorder characterized by low red blood cells and/or hemoglobin and abnormally large, immature circulating red blood cells.

CSP Definition: anemias associated with impaired DNA synthesis in bone marrow progenitor cells leading to odd shaped, macrocytic, or dysfunctional erythrocytes; usually caused by B12 or folate deficiency.

MSH Definition: A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.

Synonyms & Abbreviations: (see Synonym Details)
ANAEMIA MEGALOBLASTIC
ANEMIA MEGALOBLASTIC
Anemia, Megaloblastic [Disease/Finding]
Anemia, Megaloblastic
Anemias, Megaloblastic
Megaloblastic anaemia NOS
Megaloblastic anaemia
Megaloblastic anemia (disorder)
Megaloblastic anemia NOS
Megaloblastic anemia, NOS
Megaloblastic Anemias
megaloblastic anemia

External Source Codes: 
NCI Thesaurus Code C34382 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X20C8 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0427-2735 CSP
DX 19910101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D008534 MSH
HN 91(75); was see under ANEMIA, MACROCYTIC 1975-90 MSH
HN ETOH descriptor 2000. AOD
HPO_COMMENT Megaloblastic anemia can result from folic acid deficiency or vitamin B12 deficiency. Folate deficiency leads to an impairment of DNA synthesis such that the cell cycle cannot progress from the G2 growth stage to the mitosis stage, in turn leading to continuing cell growth without division, which presents as macrocytosis. HPO
MDA 19990101 MSH
MESH_DEFINITION A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS. NDFRT
MESH_DUI D000749 NDFRT
MESH_NAME Anemia, Megaloblastic NDFRT
MESH_UI M0001134 NDFRT
MMR 20090706 MSH
MN C15.378.071.252.196 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Megaloblastic Anemia NCI
NUI N0000000393 NDFRT
OL search ANEMIA, MACROCYTIC 1966-74 MSH
PM 91; was see under ANEMIA, MACROCYTIC 1975-90 MSH
PRIMARY_PATH 10002065$10002067$10002086$10005329$Anaemia megaloblastic$Anaemias NEC$Anaemias nonhaemolytic and marrow depression$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3108980 RXNORM
RXAUI 3108981 RXNORM
RXCUI 1024995 RXNORM
SID HP:0004858 HPO
SNOMED_CID 53165003 NDFRT
SNOMEDID DC-12010 SNOMEDCT_US
SOS Blood disorder characterized by chronic premature destruction of red blood cells. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D53.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D53.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D53.1 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D53.1 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X20C8 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-12010 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T002240 MSH
TH NLM (1975) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002888

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