skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Autoimmune hemolytic anemia (CUI C0002880) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0002880

NCI Thesaurus Code: C34378  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An acquired anemia caused by destruction of the red blood cells by autoantibodies. Causes include autoimmune disorders, lymphoproliferative disorders, and infections.

GARD Definition: Autoimmune hemolytic anemia (AIHA) occurs when your immune system makes antibodies that attack your red blood cells. This causes a drop in the number of red blood cells, leading to hemolytic anemia. Symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. AIHA can be primary (idiopathic) or result from an underlying disease or medication. The condition may develop gradually or occur suddenly. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia.  Treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. - this information is from GARD/ORDR/NCATS.

HPO Definition: An autoimmune form of hemolytic anemia. [HPO:probinson]

NCI-GLOSS Definition: A condition in which the body's immune system stops red blood cells from forming or causes them to clump together. Autoimmune hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL).

NICHD Definition: An acquired anemia caused by destruction of the erythrocytes by autoantibodies.

CSP Definition: due to acquired antierythrocyte autoantibodies causing premature erythrocyte clearance by the spleen; antibodies can be warm or cold active; usually slow developing and treatable.

MSH Definition: Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.

Synonyms & Abbreviations: (see Synonym Details)
Acquired autoimmune hemolytic anemia
AHA
AIHA
Anaemia haemolytic autoimmune
ANEMIA HEMOLYTIC AUTOIMMUNE (NOS)
Anemia hemolytic autoimmune
Anemia, Autoimmune Hemolytic
ANEMIA, HEMOLYTIC, ACQUIRED AUTOIMMUNE
Anemia, Hemolytic, Autoimmune [Disease/Finding]
Anemia, Hemolytic, Autoimmune
Anemias, Autoimmune Hemolytic
Autoimmun hemolytic anem
Autoimmune haemolytic anaemia NOS
Autoimmune haemolytic anaemias
Autoimmune haemolytic anaemia
Autoimmune hemolytic anemia (disorder)
Autoimmune hemolytic anemia NOS
Autoimmune hemolytic anemias
autoimmune hemolytic anemia
Hemolytic anemia, autoimmune
Hemolytic Anemias, Autoimmune
Idiopathic autoimmune hemolytic anemia
immunohemolytic anemia
Secondary autoimmune haemolytic anaemia
Secondary autoimmune hemolytic anemia (disorder)
Secondary autoimmune hemolytic anemia

External Source Codes: 
NCI Thesaurus Code C34378 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID XU6sW SNOMEDCT_US
CTV3ID XUcXs SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0427-1178 CSP
DISEASE_IDENTIFIER_ID 17413 GARD
DISEASE_IDENTIFIER_ID 17414 GARD
DISEASE_IDENTIFIER_ID 17415 GARD
DISEASE_IDENTIFIER_ID 34744 GARD
DISEASE_IDENTIFIER_ID 34745 GARD
DX 19680101 MSH
EFFECTIVE_TIME 20050131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 1968; use ANEMIA, IDIOPATHIC ACQUIRED HEMOLYTIC 1965-1967 MSH
ICA Use additional E code to identify cause, if drug-induced ICD9CM
ICE Autoimmune hemolytic disease (cold type) (warm type); Chronic cold hemagglutinin disease; Cold agglutinin disease or hemoglobinuria; Hemolytic anemia: {cold type (secondary) (symptomatic); drug-induced; warm type (secondary) (symptomatic)} ICD9CM
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-01-01T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS. NDFRT
MESH_DUI D000744 NDFRT
MESH_NAME Anemia, Hemolytic, Autoimmune NDFRT
MESH_UI M0001127 NDFRT
MIMTYPE 0 OMIM
MIMTYPEMEANING Other, mainly phenotypes with suspected mendelian basis OMIM
MIMTYPEVALUE none OMIM
MMR 20110624 MSH
MN C15.378.071.141.125 MSH
MN C20.111.175 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Autoimmune Hemolytic Anemia NCI
NUI N0000000388 NDFRT
PM 1968; see ANEMIA, IDIOPATHIC ACQUIRED HEMOLYTIC 1965-1967 MSH
PRIMARY_PATH 10073785$10002052$10018911$10005329$Autoimmune haemolytic anaemia$Anaemias haemolytic immune$Haemolyses and related conditions$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5870/autoimmune-hemolytic-anemia/resources/1 GARD
RXAUI 3108959 RXNORM
RXAUI 3108960 RXNORM
RXAUI 3112567 RXNORM
RXAUI 3171812 RXNORM
RXCUI 1022925 RXNORM
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_ADDVERSION 20.1 MDR
SMQ_TERM_ADDVERSION 8.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT H MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 16.1 MDR
SMQ_TERM_LMVERSION 20.1 MDR
SMQ_TERM_LMVERSION 8.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SMQ_TERM_WEIGHT 3 MDR
SNOMED_CID 413603009 NDFRT
SOS Excludes: Evans' syndrome (287.32); hemolytic disease of newborn (773.0-773.5) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D59.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D59.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D59.1 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D59.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF CHRONIC COLD AGGLUTININ DISEASE ASSOCIATED WITH B-CELL NEOPLASM CHOOSE C85.10 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF CHRONIC COLD AGGLUTININ DISEASE ASSOCIATED WITH B-CELL NEOPLASM CHOOSE D59.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO CHRONIC INFLAMMATORY DISEASE CHOOSE D59.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO CHRONIC INFLAMMATORY DISEASE CHOOSE R69 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO LYMPHOPROLIFERATIVE DISORDER CHOOSE D47.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO LYMPHOPROLIFERATIVE DISORDER CHOOSE D59.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO RHEUMATIC DISORDER CHOOSE D59.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO RHEUMATIC DISORDER CHOOSE M79.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO SYSTEMIC LUPUS ERYTHEMATOSUS CHOOSE D59.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO SYSTEMIC LUPUS ERYTHEMATOSUS CHOOSE M32.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO ULCERATIVE COLITIS CHOOSE D59.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY AUTOIMMUNE HEMOLYTIC ANEMIA CO-OCCURRENT AND DUE TO ULCERATIVE COLITIS CHOOSE K51.918 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SECONDARY PAROXYSMAL COLD HEMOGLOBINURIA CHOOSE D59.6 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 127056008 | Chronic cold agglutinin disease associated with B-cell neoplasm | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 50253007 | Secondary paroxysmal cold hemoglobinuria | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732960002 | Secondary autoimmune hemolytic anemia co-occurrent and due to systemic lupus erythematosus | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732962005 | Secondary autoimmune hemolytic anemia co-occurrent and due to chronic inflammatory disease | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732963000 | Secondary autoimmune hemolytic anemia co-occurrent and due to lymphoproliferative disorder | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732965007 | Secondary autoimmune hemolytic anemia co-occurrent and due to rheumatic disorder | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732966008 | Secondary autoimmune hemolytic anemia co-occurrent and due to ulcerative colitis | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C85.10 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D47.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D59.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D59.6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K51.918 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M32.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M79.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~R69 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU6sW SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUcXs SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T002223 MSH
TERMUI T637870 MSH
TERMUI T640359 MSH
TERMUI T750928 MSH
TERMUI T750929 MSH
TH NLM (1968) MSH
TH NLM (2006) MSH
TH NLM (2010) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002880

Mainbox Bottom