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Aplastic Anemia (CUI C0002874) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002874

NCI Thesaurus Code: C2870  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors.

GARD Definition: Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic. - this information is from GARD/ORDR/NCATS.

HPO Definition: Aplastic anemia is defined as pancytopenia with a hypocellular marrow. [HPO:probinson, pmid:21239768]

MEDLINEPLUS Definition: 

Aplastic anemia is a rare but serious blood disorder. If you have it, your bone marrow doesn't make enough new blood cells. Causes include

  • Toxic substances, such as pesticides, arsenic, and benzene
  • Radiation therapy and chemotherapy for cancer
  • Certain medicines
  • Infections such as hepatitis, Epstein-Barr virus, or HIV
  • Autoimmune disorders
  • Certain inherited conditions
  • Pregnancy

In many people, the cause is unknown.

Symptoms include fatigue, weakness, dizziness, and shortness of breath. It can cause heart problems such as an irregular heartbeat, an enlarged heart, and heart failure. You may also have frequent infections and bleeding.

Your doctor will diagnose aplastic anemia based on your medical and family histories, a physical exam, and test results. Once your doctor knows the cause and severity of the condition, he or she can create a treatment plan for you. Treatments include blood transfusions, blood and marrow stem cell transplants, and medicines.

NIH: National Heart, Lung, and Blood Institute

NCI-GLOSS Definition: A condition in which the bone marrow is unable to produce blood cells.

NICHD Definition: A syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia.

CSP Definition: anemia associated with a fatty, hypocellular bone marrow and global dyshematopoiesis; can be idiopathic or due to microbial, metabolic, autoimmune, or other abnormality.

MSH Definition: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

Synonyms & Abbreviations: (see Synonym Details)
ANAEMIA APLASTIC
ANEMIA APLASTIC
Anemia, Aplastic [Disease/Finding]
ANEMIA, APLASTIC
Anemias, Aplastic
Aplastic anaemia, unspecified
Aplastic anaemia
Aplastic anemia (disorder)
Aplastic anemia NOS
Aplastic anemia, unspecified
Aplastic Anemias
aplastic anemia
Erythroid aplasia
Haematopoietic aplasia
Hematopoietic aplasia (disorder)
Hematopoietic aplasia

External Source Codes: 
NCI Thesaurus Code C2870 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN a bone marrow dis MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID XU4gf SNOMEDCT_US
CTV3ID XU4k4 SNOMEDCT_US
DATE_CREATED 01/04/2012 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2006-06-02 PDQ
DATE_LAST_MODIFIED 2010-01-27 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0427-0486 CSP
DISEASE_IDENTIFIER_ID 17332 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
GENELOCUS ,7,q,1,1, OMIM
GENESYMBOL SBDS OMIM
GENESYMBOL SDS OMIM
HAS_GARD_PAGE true GARD
HPO_COMMENT Aplastic anemia is characterized by reduced numbers of all blood cell types (red blood cells, white blood cells, and platelets) owing to reduced production. HPO
IAN DEFAULT ICD10
ICE Anemia: {aplastic (idiopathic) NOS; aregenerative; hypoplastic NOS; nonregenerative; refractory}; Medullary hypoplasia ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Hypoplastic anaemia NOS ICD10
INCLUSION_TERM Medullary hypoplasia ICD10
INCLUSION_TERM Panmyelophthisis ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2010-04-04T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. NDFRT
MESH_DUI D000741 NDFRT
MESH_NAME Anemia, Aplastic NDFRT
MESH_UI M0001120 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN C15.378.071.085 MSH
MN C15.378.190.196 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/aplasticanemia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/aplasticanemia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C2870 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Aplastic Anemia NCI
NUI N0000000385 NDFRT
ORDER_NO 03432 ICD10CM
ORIG_STY Disease/diagnosis PDQ
PRIMARY_PATH 10002967$10026847$10002086$10005329$Aplastic anaemia$Marrow depression and hypoplastic anaemias$Anaemias nonhaemolytic and marrow depression$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5836/aplastic-anemia/resources/1 GARD
RXAUI 3108932 RXNORM
RXAUI 3108933 RXNORM
RXAUI 5038658 RXNORM
RXCUI 1023343 RXNORM
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_ADDVERSION 8.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 16.1 MDR
SMQ_TERM_LMVERSION 8.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 304132006 NDFRT
SNOMED_CID 306058006 NDFRT
SNOMEDID DC-10006 SNOMEDCT_US
SNOMEDID DF-002EA SNOMEDCT_US
SOS Excludes: refractory anemia (238.72) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D61.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D61.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D61.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D61.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D61.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU4gf SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU4k4 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-10006 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DF-002EA SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T002210 MSH
TERMUI T811411 MSH
TH NLM (1966) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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