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Amphetamine (CUI C0002658) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002658

NCI Thesaurus Code: C62006  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A synthetic substance related to natural sympathomimetic amines. Amphetamine appears to exert its central nervous system (CNS) and peripheral effects indirectly by inducing the release of biogenic amines from their storage sites in nerve terminals. This agent is a commonly abused psychostimulant drug, which may be snorted, taken orally, smoked, or injected. Amphetamine induces psychologic dependence which is manifested by elevated mood, increased wakefulness, concentration, physical performance and a feeling of well-being. With sustained use, the effects of tachycardia and enhanced alertness diminish while psychotoxic effects such as hallucinations and delusions may occur. (NCI04)

SNOMEDCT_US Definition: Chemical racemic free base or equal parts of enantiomers levoamphetamine and dextroamphetamine in their pure amine or salt forms.

CSP Definition: powerful central nervous system stimulant and sympathomimetic with multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase; it is also a drug of abuse and a psychotomimetic.

MSH Definition: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Synonyms & Abbreviations: (see Synonym Details)
1-phenyl-2-aminopropane
1-phenylpropan-2-amine (substance)
1-phenylpropan-2-amine
1-Phenylpropan-2-amin
alpha-Methylbenzeneethaneamine
alpha-Methylphenylethylamine
Amfetamine
Amfetaminum
Amphetamine (product)
Amphetamine [Chemical/Ingredient]
amphetamine
Amphetamin
Benzedrine
Benzeneethanamine, alpha-methyl-, (+-)-
beta-Aminopropylbenzene
d,1-alpha- Methylphenethylamine
Desoxynorephedrine
Desoxynorephedrin
dl-alpha-methylphenethylamine
dl-Amphetamine
Phenamine
Phenopromin
Phenylaminopropane
α-methylbenzeneethaneamine
α-methylphenethylamine
β-aminopropylbenzene

External Source Codes: 
NCI Thesaurus Code C62006 (see NCI Thesaurus info)
CAS Registry Number 60-15-1 (see NLM ChemIDplus info)
CAS Registry Number 300-62-9 (see NLM ChemIDplus info)
FDA UNII Code CK833KGX7E
NSC Code 27159 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN a specific chem: do not confuse with AMPHETAMINES; d-amphetamine = DEXTROAMPHETAMINE; N-methylamphetamine = METHAMPHETAMINE MSH
AQL AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:2679 NCI
Chemical_Formula C9H13N NCI
Contributing_Source FDA NCI
CTV3ID x01Bt SNOMEDCT_US
CTV3ID XUnMb SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2268-4026 CSP
DX 19660101 MSH
EC analogs & derivatives:Amphetamines MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20140731 SNOMEDCT_US
FDA_UNII_CODE CK833KGX7E DRUGBANK
FDA_UNII_CODE CK833KGX7E NDFRT
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. NDFRT
MESH_DUI D000661 NDFRT
MESH_NAME Amphetamine NDFRT
MESH_UI M0001012 NDFRT
MMR 20160705 MSH
MN D02.092.471.683.152.110 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005864 NDFRT
NUI N0000147705 NDFRT
PA D000697 MSH
PA D013566 MSH
PA D015259 MSH
PA D018663 MSH
PA D018759 MSH
PA D018765 MSH
RN CK833KGX7E MSH
RR 300-62-9 (Amphetamine) MSH
RR 60-13-9 (Amphetamine Sulfate) MSH
RR 60-15-1 (Amphetamine) MSH
RR 6DPV8NK46S MSH
RXAUI 2067800 RXNORM
RXAUI 22004 RXNORM
RXAUI 3100715 RXNORM
RXAUI 3100716 RXNORM
RXAUI 3108083 RXNORM
RXAUI 3108602 RXNORM
RXAUI 3108614 RXNORM
RXAUI 3117109 RXNORM
RXAUI 3146076 RXNORM
RXAUI 3219656 RXNORM
RXAUI 3219802 RXNORM
RXAUI 6394961 RXNORM
RXAUI 6395007 RXNORM
RXCUI 725 RXNORM
SID APRD00480 DRUGBANK
SPL_SET_ID 1714de28-482e-463f-e91f-eeaaaa83d17f MTHSPL
SPL_SET_ID 288dafc4-fe6e-4891-832f-511022c87445 MTHSPL
SPL_SET_ID 34726042-2386-4c19-abec-440769fff99a MTHSPL
SPL_SET_ID 35744538-1704-4ee0-954d-52710cf3456d MTHSPL
SPL_SET_ID 39ebdc79-5403-4c2e-b366-12f8491e8bca MTHSPL
SPL_SET_ID 49289133-6071-406e-8b18-73a6e4db8782 MTHSPL
SPL_SET_ID 49b7d111-7045-4116-8988-ba93c7d63491 MTHSPL
SPL_SET_ID 4cc84b5d-9b56-4b80-a201-6e4075727d44 MTHSPL
SPL_SET_ID 6670decb-e6bb-462e-9cec-cd70fde20b58 MTHSPL
SPL_SET_ID 6f637e8d-7c2e-47fa-a43c-3250c51aed77 MTHSPL
SPL_SET_ID 72ddd1c9-ddbd-4c95-acd9-003189a353a3 MTHSPL
SPL_SET_ID 89c4b21a-1a65-41ef-8718-1619c2ba8591 MTHSPL
SPL_SET_ID 9af67219-9b37-45d0-ac52-647cbfacd296 MTHSPL
SPL_SET_ID a200fc5e-faab-4471-af77-64da407fa131 MTHSPL
SPL_SET_ID a582d57f-d191-4ca5-b105-585b2d8a0e3e MTHSPL
SPL_SET_ID a8a7eb93-4192-4826-bbf1-82c06634f553 MTHSPL
SPL_SET_ID afdedf03-f393-454d-9158-99e36071fa93 MTHSPL
SPL_SET_ID aff45863-ffe1-4d4f-8acf-c7081512a6c0 MTHSPL
SPL_SET_ID b6c8d902-4d43-46b0-b96c-00d8bed1b3dd MTHSPL
SPL_SET_ID bb12811f-4cce-4010-aa48-d17c46ca1d3a MTHSPL
SPL_SET_ID bb177997-e10c-49a7-88c6-040852d05fdc MTHSPL
SPL_SET_ID c1179269-00b5-48ea-972d-31e614e99b7e MTHSPL
SPL_SET_ID c5c2d060-452c-4f76-ad93-2e41fd8f06c2 MTHSPL
SPL_SET_ID cffbbb15-d776-41ae-a8a6-687f2c07bfa4 MTHSPL
SPL_SET_ID d63a086a-32e2-49e2-949e-64e4c922775a MTHSPL
SPL_SET_ID f0618c47-ca45-4652-9002-4465f6bc7fe4 MTHSPL
SPL_SET_ID F0FC4960-8262-48E1-805C-DAE63FD045B0 MTHSPL
SPL_SET_ID f22635fe-821d-4cde-aa12-419f8b53db81 MTHSPL
SPL_SET_ID f469fb38-0380-4621-9db3-a4f429126156 MTHSPL
SPL_SET_ID f55aba1f-9404-4a49-8e3b-7a66ce538c60 MTHSPL
SPL_SET_ID f6c30ba1-53d0-4f85-a515-81acfb922e73 MTHSPL
SPL_SET_ID fa0a9e70-f4bd-41c4-9dc0-8b8a4b842ca1 MTHSPL
SPL_SET_ID fdeb76f5-e6af-4f8b-b901-731d65a70b18 MTHSPL
SPL_SET_ID ffd56d70-d884-43be-a994-6e70a10e823e MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01Bt SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUnMb SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T001988 MSH
TERMUI T001989 MSH
TERMUI T001992 MSH
TERMUI T001993 MSH
TERMUI T001995 MSH
TH BAN (19XX) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2230^Active/Master NDFRT
VANDF_RECORD 50.6^1390^Active/Master NDFRT
VUID 4019611 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002658

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