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Amoxicillin (CUI C0002645) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002645

NCI Thesaurus Code: C237  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

PDQ Definition: A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug used to treat some bacterial infections. Amoxicillin is a form of penicillin that is made in the laboratory. It kills certain types of bacteria. It is a type of antibiotic.

MSH Definition: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.

Synonyms & Abbreviations: (see Synonym Details)
26787-78-0
277174
6-(P-Hydroxy-alpha-aminophenylacetamido)penicillanic acid
6-(p-hydroxy-α-aminophenylacetamido)penicillanic acid
alpha-amino-P-Hydroxybenzylpenicillin
Amoxicilina
Amoxicillin (substance)
Amoxicillin [Chemical/Ingredient]
Amoxicillin trihydrate (substance)
Amoxicillin Trihydrate
Amoxicilline
Amoxicillinum
amoxicillin
Amoxil
Amoxycillin
Amox
AMPC
AX
BRL 2333
BRL-2333
BRL2333
Hydroxyampicillin
p-Hydroxyampicillin
Polymox
Product containing amoxicillin (medicinal product)
Product containing amoxicillin
Trihydrate, Amoxicillin
Trimox
Utimox
Wymox
α-amino-p-hydroxybenzylpenicillin

External Source Codes: 
NCI Thesaurus Code C237 (see NCI Thesaurus info)
CAS Registry Number 61336-70-7 (see NLM ChemIDplus info)
FDA UNII Code 804826J2HU
NSC Code 277174 (see NCI DTP info)
PDQ Closed Trial Search ID 42310
PDQ Open Trial Search ID 42310 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:51254 NCI
Chemical_Formula C16H19N3O5S.3H2O NCI
Contributing_Source FDA NCI
CTV3ID e31.. SNOMEDCT_US
CTV3ID XUObk SNOMEDCT_US
CTV3ID XUVz9 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0199-8025 CSP
DX 19800101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 804826J2HU NDFRT
FDA_UNII_CODE 9EM05410Q9 DRUGBANK
HN 80(75); was see under AMPICILLIN 1975-79 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19741111 MSH
MESH_DEFINITION A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration. NDFRT
MESH_DUI D000658 NDFRT
MESH_NAME Amoxicillin NDFRT
MESH_UI M0001009 NDFRT
MMR 20160527 MSH
MN D02.065.589.099.750.750.050.050 MSH
MN D02.886.108.750.750.050.050 MSH
MN D03.633.100.300.750.750.050.050 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C237 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005840 NDFRT
NUI N0000145984 NDFRT
NUI N0000145985 NDFRT
ORIG_STY Drug/agent PDQ
PA D000900 MSH
PID 5558 PDQ
PM 80; was see under AMPICILLIN 1975-79 MSH
RN 0 MSH
RN 804826J2HU MSH
RR 26787-78-0 (Amoxicillin) MSH
RR 26889-93-0 ((R*)-isomer) MSH
RR 34642-78-9 (mono-K salt) MSH
RR 544Y3D6MYH MSH
RR 61336-70-7 (Amoxicillin trihydrate) MSH
RR 9EM05410Q9 MSH
RXAUI 1184250 RXNORM
RXAUI 1910439 RXNORM
RXAUI 2067793 RXNORM
RXAUI 21855 RXNORM
RXAUI 2598348 RXNORM
RXAUI 2621280 RXNORM
RXAUI 2996544 RXNORM
RXAUI 3100538 RXNORM
RXAUI 3100539 RXNORM
RXAUI 3100620 RXNORM
RXAUI 3100621 RXNORM
RXAUI 3108584 RXNORM
RXAUI 3108587 RXNORM
RXAUI 3108594 RXNORM
RXAUI 3173945 RXNORM
RXAUI 346112 RXNORM
RXAUI 5911024 RXNORM
RXAUI 5930184 RXNORM
RXAUI 914362 RXNORM
RXCUI 10835 RXNORM
RXCUI 133008 RXNORM
RXCUI 203169 RXNORM
RXCUI 220466 RXNORM
RXCUI 723 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
SID APRD00248 DRUGBANK
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SPL_SET_ID ffb158a1-83ba-4100-9221-175aa986dc3e MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e31.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUObk SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVz9 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T001972 MSH
TERMUI T001973 MSH
TERMUI T001974 MSH
TERMUI T001976 MSH
TERMUI T001977 MSH
TERMUI T001978 MSH
TERMUI T001979 MSH
TERMUI T001980 MSH
TERMUI T837832 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH NLM (2014) MSH
TH UNK (19XX) MSH
TH USAN (1972) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^197^Active/Master NDFRT
VANDF_RECORD 50.416^198^Active/Master NDFRT
VANDF_RECORD 50.6^95^Active/Master NDFRT
VUID 4017604 NDFRT
VUID 4017605 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002645

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