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Amikacin (CUI C0002499) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002499

NCI Thesaurus Code: C61615  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.

NCI-GLOSS Definition: An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.

MSH Definition: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.

Synonyms & Abbreviations: (see Synonym Details)
1-N-(L(-)-gamma-amino-alpha-Hydroxybutyryl)kanamycin a
Amicacin
Amikacin (substance)
Amikacin [Chemical/Ingredient]
Amikacina
Amikacine
Amikacinum
Amikacin
AMIKA
D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-
O-3-amino-3-Deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine
Product containing amikacin (medicinal product)
Product containing amikacin

External Source Codes: 
NCI Thesaurus Code C61615 (see NCI Thesaurus info)
CAS Registry Number 37517-28-5 (see NLM ChemIDplus info)
FDA UNII Code 84319SGC3C

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:2637 NCI
Chemical_Formula C22H43N5O13 NCI
Contributing_Source FDA NCI
CTV3ID e82.. SNOMEDCT_US
CTV3ID XUWta SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19870101 MSH
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 84319SGC3C DRUGBANK
FDA_UNII_CODE 84319SGC3C NDFRT
HN 87(75); was see under KANAMYCIN 1975-86 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19741119 MSH
MESH_DEFINITION A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics. NDFRT
MESH_DUI D000583 NDFRT
MESH_NAME Amikacin NDFRT
MESH_UI M0000903 NDFRT
MMR 20160705 MSH
MN D09.408.051.476.060 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006770 NDFRT
NUI N0000147698 NDFRT
PA D000900 MSH
PM 87; was see under KANAMYCIN 1975-86 MSH
RN 84319SGC3C MSH
RR 37517-28-5 (Amikacin) MSH
RR 39831-55-5 (Amikacin Sulfate) MSH
RR N6M33094FD MSH
RXAUI 19755 RXNORM
RXAUI 2067720 RXNORM
RXAUI 3099357 RXNORM
RXAUI 3099358 RXNORM
RXAUI 3108130 RXNORM
RXAUI 3108136 RXNORM
RXAUI 3137841 RXNORM
RXAUI 6394954 RXNORM
RXAUI 8230106 RXNORM
RXCUI 641 RXNORM
SID APRD00550 DRUGBANK
SPL_SET_ID 0b56f6df-a05d-4520-8bf0-d7cefe20f6ad MTHSPL
SPL_SET_ID 5efe8d50-3138-43b4-bdb0-2d8a66fcdc96 MTHSPL
SPL_SET_ID 6ec3129b-c53b-4bdb-913d-a2d0060fa140 MTHSPL
SPL_SET_ID a43188fa-f228-4acd-8a5d-9a3462034f4b MTHSPL
SPL_SET_ID a47f8cf6-dbdc-46f7-b0a0-e56adcb8b087 MTHSPL
SPL_SET_ID c0f57839-1c9b-49e5-8c7a-708e2d16495d MTHSPL
SPL_SET_ID f260ff2a-76a0-4672-9516-91c344b67890 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e82.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWta SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T001771 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2221^Active/Master NDFRT
VANDF_RECORD 50.6^456^Active/Master NDFRT
VUID 4019602 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002499

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