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Amblyopia (CUI C0002418) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002418

NCI Thesaurus Code: C118764  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Decreased vision that results from abnormal visual development.

HPO Definition: Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways. [HPO:probinson]

MEDLINEPLUS Definition: 

Amblyopia, or "lazy eye," is the most common cause of visual impairment in children. It happens when an eye fails to work properly with the brain. The eye may look normal, but the brain favors the other eye. In some cases, it can affect both eyes. Causes include

  • Strabismus - a disorder in which the two eyes don't line up in the same direction
  • Refractive error in an eye - when one eye cannot focus as well as the other, because of a problem with its shape. This includes nearsightedness, farsightedness, and astigmatism.
  • Cataract - a clouding in the lens of the eye

It can be hard to diagnose amblyopia. It is often found during a routine vision exam.

Treatment for amblyopia forces the child to use the eye with weaker vision. There are two common ways to do this. One is to have the child wear a patch over the good eye for several hours each day, over a number of weeks to months. The other is with eye drops that temporarily blur vision. Each day, the child gets a drop of a drug called atropine in the stronger eye. It is also sometimes necessary to treat the underlying cause. This could include glasses or surgery.

NIH: National Eye Institute

NICHD Definition: Decreased vision that results from abnormal visual development.

CSP Definition: impairment of vision without detectable organic lesion of the eye.

MSH Definition: A nonspecific term referring to impaired vision. Major subcategories include stimulus deprivation-induced amblyopia and toxic amblyopia. Stimulus deprivation-induced amblyopia is a developmental disorder of the visual cortex. A discrepancy between visual information received by the visual cortex from each eye results in abnormal cortical development. STRABISMUS and REFRACTIVE ERRORS may cause this condition. Toxic amblyopia is a disorder of the OPTIC NERVE which is associated with ALCOHOLISM, tobacco SMOKING, and other toxins and as an adverse effect of the use of some medications.

Synonyms & Abbreviations: (see Synonym Details)
Amblyopia (disorder)
Amblyopia [Disease/Finding]
Amblyopia NOS
Amblyopia, unspecified
Amblyopias
amblyopia
Amblyopic
Eye, Lazy
Eyes, Lazy
Lazy eye (finding)
Lazy Eyes
Lazy eye
Unspecified amblyopia
Wandering eyes
Wandering eye

External Source Codes: 
NCI Thesaurus Code C118764 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X75bA SNOMEDCT_US
CTV3ID XUX1K SNOMEDCT_US
DATE_CREATED 04/29/2014 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1114-9655 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
HPO_COMMENT Ambylopia can result from visual deprivation during the critical period of development of visual abilities which lasts to about the age of 8 years. Thus, ambylopia can result from strabismus, anisometropia, or high hypermetropia in there is a failure to form a focused image in one or both eyes. HPO
MDA 19990101 MSH
MESH_DEFINITION A nonspecific term referring to impaired vision. Major subcategories include stimulus deprivation-induced amblyopia and toxic amblyopia. Stimulus deprivation-induced amblyopia is a developmental disorder of the visual cortex. A discrepancy between visual information received by the visual cortex from each eye results in abnormal cortical development. STRABISMUS and REFRACTIVE ERRORS may cause this condition. Toxic amblyopia is a disorder of the OPTIC NERVE which is associated with ALCOHOLISM, tobacco SMOKING, and other toxins and as an adverse effect of the use of some medications. NDFRT
MESH_DUI D000550 NDFRT
MESH_NAME Amblyopia NDFRT
MESH_UI M0000854 NDFRT
MMR 20040719 MSH
MN C10.228.140.055 MSH
MN C10.597.751.941.073 MSH
MN C11.966.073 MSH
MN C23.888.592.763.941.073 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/amblyopia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/amblyopia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Eye Institute http://www.nei.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Amblyopia NCI
NUI N0000000364 NDFRT
ORDER_NO 09570 ICD10CM
PRIMARY_PATH 10001906$10001910$10047518$10015919$Amblyopia$Amblyopic vision impairment$Vision disorders$Eye disorders MDR
PRIMARY_SOC 10015919 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
REF HPO:skoehler HPO
REF orcid.org/0000-0001-5208-3432, orcid.org/0000-0001-5889-4463 HPO
RXAUI 3108011 RXNORM
RXAUI 3108012 RXNORM
RXCUI 1024997 RXNORM
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 267627009 NDFRT
SNOMED_CID 387742006 NDFRT
SOS Inability to see, although the eye itself appears to be structurally normal. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS H53.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~H53.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS H53.009 | CONSIDER LATERALITY SPECIFICATION | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS H57.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~H53.009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~H57.8 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X75bA SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUX1K SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T001673 MSH
TERMUI T363925 MSH
TH NLM (1966) MSH
TH NLM (2000) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002418

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