|Terms & Properties|
Concept Unique Identifier (CUI): C0002395
NCI Thesaurus Code: C2866 (see NCI Thesaurus info)
Semantic Type: Disease or Syndrome
NCIt Definition: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
RADLEX Definition: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques; neurofibrillary tangles; and neuropil threads. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) [MeSH]
GARD Definition: Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people. About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older.
The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).- this information is from GARD/ORDR/NCATS.
HPO Definition: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads. [HPO:probinson]
Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities.
AD begins slowly. It first involves the parts of the brain that control thought, memory and language. People with AD may have trouble remembering things that happened recently or names of people they know. A related problem, mild cognitive impairment (MCI), causes more memory problems than normal for people of the same age. Many, but not all, people with MCI will develop AD.
In AD, over time, symptoms get worse. People may not recognize family members. They may have trouble speaking, reading or writing. They may forget how to brush their teeth or comb their hair. Later on, they may become anxious or aggressive, or wander away from home. Eventually, they need total care. This can cause great stress for family members who must care for them.
AD usually begins after age 60. The risk goes up as you get older. Your risk is also higher if a family member has had the disease.
No treatment can stop the disease. However, some drugs may help keep symptoms from getting worse for a limited time.
NIH: National Institute on Aging
NCI-GLOSS Definition: A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality.
CSP Definition: neurodegenerative disorder of the CNS resulting in progressive loss of memory and intellectual functions; begins in the middle or later years; characterized by brain lesions such as neurofibrillary tangles and neuritic plaques.
MSH Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Synonyms & Abbreviations: (see Synonym Details)
|AD - Alzheimer's disease|
|Alzheimer Dementia (AD)|
|Alzheimer Disease [Disease/Finding]|
|Alzheimer Type Dementia (ATD)|
|Alzheimer Type Dementia|
|Alzheimer Type Senile Dementia|
|Alzheimer's disease (disorder)|
|Alzheimer's disease, unspecified|
|Alzheimer-Type Dementia (ATD)|
|dementia Alzheimer type|
|Dementia Alzheimer's type|
|Dementia in Alzheimer's disease, unspecified|
|Dementia in Alzheimer's disease|
|DEMENTIA OF THE ALZHEIMER TYPE|
|Dementia of the Alzheimer's type NOS|
|Dementia of the Alzheimer's type|
|Dementia, Alzheimer (AD)|
|Dementia, Alzheimer Type|
|Dementia, Alzheimer-Type (ATD)|
|Dementia, Primary Senile Degenerative|
|Primary Senile Degenerative Dementia|
|SENILE DEMENTIA OF THE ALZHEIMER TYPE|
|Senile Dementia, Alzheimer Type|
External Source Codes:
|NCI Thesaurus Code||C2866 (see NCI Thesaurus info)|
|AQL||BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI||MSH|
|EXCLUDES1||senile degeneration of brain NEC (G31.1)||ICD10CM|
|EXCLUDES1||senile dementia NOS (F03)||ICD10CM|
|EXCLUDES1||senility NOS (R41.81)||ICD10CM|
|HN||1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999||MSH|
|HPO_COMMENT||Note that this is a bundled term that refers to a disease rather than to phenotypic features. It is retained for convenience since Alzheimer disease is used for annotation of other diseases (e.g., Down syndrome) as if it were a feature. If possible it is preferable to annotate with the precise phenotypic features.||HPO|
|INCLUSION_TERM||senile and presenile forms||ICD10|
|MESH_DEFINITION||A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)||NDFRT|
|MIMTYPEMEANING||Phenotype description, molecular basis known.||OMIM|
|MP_OTHER_LANGUAGE_URL||Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Chinese - Simplified||MEDLINEPLUS|
|MP_OTHER_LANGUAGE_URL||Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Chinese - Traditional||MEDLINEPLUS|
|MP_PRIMARY_INSTITUTE_URL||National Institute on Aging http://www.nia.nih.gov/||MEDLINEPLUS|
|PM||1998; see ALZHEIMER'S DISEASE 1984-1997, see DEMENTIA, PRESENILE 1967-1983, see PSYCHOSES, PRESENILE 1963-1966; for DEMENTIA PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE, SENILE see DEMENTIA 1981-1999; for DEMENTIA, SENILE see DEMENTIA 1966-1999||MSH|
|PRIMARY_PATH||10012271$10001897$10057167$10029205$Dementia Alzheimer's type$Alzheimer's disease (incl subtypes)$Mental impairment disorders$Nervous system disorders||MDR|
|SOS||Loss of cholinergic neurons in nucleus basalis of Meynert leading to development of senile plaques and neurofibrillary tangles.||AOD|
|SUBSET_MEMBER||6011000124106~MAPADVICE~ALWAYS F02.80 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED||SNOMEDCT_US|
|SUBSET_MEMBER||6011000124106~MAPADVICE~ALWAYS G30.9 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED||SNOMEDCT_US|
|USE_ADDITIONAL||code to identify:||ICD10CM|
|USE_ADDITIONAL||delirium, if applicable (F05)||ICD10CM|
|USE_ADDITIONAL||dementia with behavioral disturbance (F02.81)||ICD10CM|
|USE_ADDITIONAL||dementia without behavioral disturbance (F02.80)||ICD10CM|
Additional Concept Data: (none)