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Alzheimer's Disease (CUI C0002395) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002395

NCI Thesaurus Code: C2866  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

RADLEX Definition: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques; neurofibrillary tangles; and neuropil threads. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) [MeSH]

GARD Definition: Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. Alzheimer disease currently affects about 5 million people. About 75 percent of Alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. Although the cause of these cases is unknown, genetic changes are likely to play a role. Virtually all sporadic Alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older.

The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).

- this information is from GARD/ORDR/NCATS.

HPO Definition: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads. [HPO:probinson]

MEDLINEPLUS Definition: 

Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities.

AD begins slowly. It first involves the parts of the brain that control thought, memory and language. People with AD may have trouble remembering things that happened recently or names of people they know. A related problem, mild cognitive impairment (MCI), causes more memory problems than normal for people of the same age. Many, but not all, people with MCI will develop AD.

In AD, over time, symptoms get worse. People may not recognize family members. They may have trouble speaking, reading or writing. They may forget how to brush their teeth or comb their hair. Later on, they may become anxious or aggressive, or wander away from home. Eventually, they need total care. This can cause great stress for family members who must care for them.

AD usually begins after age 60. The risk goes up as you get older. Your risk is also higher if a family member has had the disease.

No treatment can stop the disease. However, some drugs may help keep symptoms from getting worse for a limited time.

NIH: National Institute on Aging

NCI-GLOSS Definition: A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality.

CSP Definition: neurodegenerative disorder of the CNS resulting in progressive loss of memory and intellectual functions; begins in the middle or later years; characterized by brain lesions such as neurofibrillary tangles and neuritic plaques.

MSH Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Synonyms & Abbreviations: (see Synonym Details)
AD - Alzheimer's disease
AD
Alzheimer Dementia (AD)
Alzheimer dementia
Alzheimer Disease [Disease/Finding]
ALZHEIMER DISEASE
ALZHEIMER DIS
Alzheimer Sclerosis
Alzheimer Syndrome
Alzheimer Type Dementia (ATD)
Alzheimer Type Dementia
Alzheimer Type Senile Dementia
Alzheimer's Dementia
Alzheimer's disease (disorder)
Alzheimer's disease, unspecified
Alzheimer's disease
Alzheimer-Type Dementia (ATD)
Alzheimers Disease
ALZHEIMERS DIS
DAT
dementia Alzheimer type
Dementia Alzheimer's type
Dementia in Alzheimer's disease, unspecified
Dementia in Alzheimer's disease
DEMENTIA OF THE ALZHEIMER TYPE
Dementia of the Alzheimer's type NOS
Dementia of the Alzheimer's type
Dementia, Alzheimer (AD)
Dementia, Alzheimer Type
Dementia, Alzheimer-Type (ATD)
Dementia, Primary Senile Degenerative
Dementia, Senile
Disease, Alzheimer's
Disease, Alzheimer
Morbus Alzheimer
Primary Senile Degenerative Dementia
Sclerosis, Alzheimer
SDAT
SENILE DEMENTIA OF THE ALZHEIMER TYPE
Senile Dementia, Alzheimer Type
Senile Dementia
Syndrome, Alzheimer

External Source Codes: 
NCI Thesaurus Code C2866 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CTV3ID F110. SNOMEDCT_US
DATE_CREATED 10/22/1998 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0485-6737 CSP
DX 19840101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 senile degeneration of brain NEC (G31.1) ICD10CM
EXCLUDES1 senile dementia NOS (F03) ICD10CM
EXCLUDES1 senility NOS (R41.81) ICD10CM
FX D016229 MSH
FX D016564 MSH
FX D016657 MSH
FX D016875 MSH
FX D016900 MSH
FX D018888 MSH
FX D020232 MSH
GENELOCUS ,6,p,2,1,.,3, OMIM
GENESYMBOL HFE1 OMIM
GENESYMBOL HFE OMIM
GENESYMBOL HLA-H OMIM
GENESYMBOL MVCD7 OMIM
GENESYMBOL TFQTL2 OMIM
HAS_GARD_PAGE true GARD
HN 1998(1963); for DEMENTIA, PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE SENILE use DEMENTIA 1981-1999; for DEMENTIA SENILE use DEMENTIA 1966-1999 MSH
HPO_COMMENT Note that this is a bundled term that refers to a disease rather than to phenotypic features. It is retained for convenience since Alzheimer disease is used for annotation of other diseases (e.g., Down syndrome) as if it were a feature. If possible it is preferable to annotate with the precise phenotypic features. HPO
IAN ASTERISK ICD10
IAN DEFAULT ICD10
INCLUSION_TERM senile and presenile forms ICD10
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) NDFRT
MESH_DUI D000544 NDFRT
MESH_NAME Alzheimer Disease NDFRT
MESH_UI M0000842 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20150630 MSH
MN C10.228.140.380.100 MSH
MN C10.574.945.249 MSH
MN F03.615.400.100 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/alzheimersdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Arabic https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Arabic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Bosnian https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Bosnian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL German https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#German MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hindi https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Hindi MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Italian https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Italian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Japanese https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Japanese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Korean https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Korean MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Polish https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Polish MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Portuguese https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Portuguese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/alzheimersdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Ukrainian https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Ukrainian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Vietnamese https://www.nlm.nih.gov/medlineplus/languages/alzheimersdisease.html#Vietnamese MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute on Aging http://www.nia.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000000363 NDFRT
ORDER_NO 05871 ICD10CM
ORDER_NO 05875 ICD10CM
PM 1998; see ALZHEIMER'S DISEASE 1984-1997, see DEMENTIA, PRESENILE 1967-1983, see PSYCHOSES, PRESENILE 1963-1966; for DEMENTIA PRESENILE and DEMENTIA, PRIMARY DEGENERATIVE, SENILE see DEMENTIA 1981-1999; for DEMENTIA, SENILE see DEMENTIA 1966-1999 MSH
PRIMARY_PATH 10012271$10001897$10057167$10029205$Dementia Alzheimer's type$Alzheimer's disease (incl subtypes)$Mental impairment disorders$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10254/alzheimer-disease/resources/1 GARD
RXAUI 3107977 RXNORM
RXAUI 3107978 RXNORM
RXAUI 3107982 RXNORM
RXAUI 3107987 RXNORM
RXAUI 3145412 RXNORM
RXAUI 3145424 RXNORM
RXAUI 3145426 RXNORM
RXAUI 3223651 RXNORM
RXAUI 3237422 RXNORM
RXAUI 5930169 RXNORM
RXAUI 5930170 RXNORM
RXAUI 5930171 RXNORM
RXAUI 5930172 RXNORM
RXCUI 1022264 RXNORM
SID HP:0006878 HPO
SID HP:0007213 HPO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 13.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 26929004 NDFRT
SOS Loss of cholinergic neurons in nucleus basalis of Meynert leading to development of senile plaques and neurofibrillary tangles. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G30.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G30.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS F02.80 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G30.9 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F02.80 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G30.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F110. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T001654 MSH
TERMUI T001655 MSH
TERMUI T010820 MSH
TERMUI T365964 MSH
TERMUI T365965 MSH
TERMUI T365981 MSH
TERMUI T366224 MSH
TERMUI T369933 MSH
TERMUI T840887 MSH
TERMUI T840888 MSH
TERMUI T843726 MSH
TERMUI T843727 MSH
TH GHR (2014) MSH
TH NLM (1966) MSH
TH NLM (1975) MSH
TH NLM (1998) MSH
TH NLM (2000) MSH
TH OMIM (2013) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code to identify: ICD10CM
USE_ADDITIONAL delirium, if applicable (F05) ICD10CM
USE_ADDITIONAL dementia with behavioral disturbance (F02.81) ICD10CM
USE_ADDITIONAL dementia without behavioral disturbance (F02.80) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002395

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