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Alprazolam (CUI C0002333) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002333

NCI Thesaurus Code: C227  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability.

PDQ Definition: A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine.

MSH Definition: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)

CSP Definition: 8-chloro-1-methyl-6-phenyl-s-triazolo benzodiazepine, has both antidepressant and anxiolytic properties; possible efficacy in alcohol withdrawal therapy; abuse can lead to habituation or addiction.

Synonyms & Abbreviations: (see Synonym Details)
28981-97-7
4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-1-methyl-6-phenyl-
8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine
Alprazolam (substance)
Alprazolam [Chemical/Ingredient]
Alprazolam Nu-Pharm Brand
Alprazolam Pfizer Brand
alprazolam
Alprazolan
Apo-Alpzar
Nu Alpraz
Nu Pharm Brand of Alprazolam
Nu-Alpraz
Nu-Pharm Brand of Alprazolam
NuAlpraz
Pfizer Brand of Alprazolam
Product containing alprazolam (medicinal product)
Product containing alprazolam
Tafil
Trankimazin
Xanax

External Source Codes: 
NCI Thesaurus Code C227 (see NCI Thesaurus info)
CAS Registry Number 28981-97-7 (see NLM ChemIDplus info)
FDA UNII Code YU55MQ3IZY
PDQ Closed Trial Search ID 39659
PDQ Open Trial Search ID 39659 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:2611 NCI
Chemical_Formula C17H13ClN4 NCI
Contributing_Source FDA NCI
CTV3ID d22.. SNOMEDCT_US
CTV3ID XUWoz SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0314-3750 CSP
DX 19870101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE YU55MQ3IZY DRUGBANK
FDA_UNII_CODE YU55MQ3IZY NDFRT
HN 87 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19860616 MSH
MESH_DEFINITION A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238) NDFRT
MESH_DUI D000525 NDFRT
MESH_NAME Alprazolam NDFRT
MESH_UI M0000806 NDFRT
MMR 20160527 MSH
MN D03.633.100.079.080.030 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C227 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006611 NDFRT
NUI N0000146413 NDFRT
ORIG_STY Drug/agent PDQ
PA D006993 MSH
PA D014151 MSH
PA D018757 MSH
PID 2314 PDQ
PM 87 MSH
RN 0 MSH
RN YU55MQ3IZY MSH
RR 28981-97-7 (Alprazolam) MSH
RXAUI 1135628 RXNORM
RXAUI 18060 RXNORM
RXAUI 2067685 RXNORM
RXAUI 2598294 RXNORM
RXAUI 2621247 RXNORM
RXAUI 2930120 RXNORM
RXAUI 3093787 RXNORM
RXAUI 3098666 RXNORM
RXAUI 3098667 RXNORM
RXAUI 3107885 RXNORM
RXAUI 3107886 RXNORM
RXAUI 3107887 RXNORM
RXAUI 3737104 RXNORM
RXCUI 202363 RXNORM
RXCUI 596 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00280 DRUGBANK
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SPL_SET_ID ff1630b4-2044-433c-96bc-0bb4ae8d42a0 MTHSPL
SPL_SET_ID ff593501-48f7-4ac3-9830-6e9d8d77ce42 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~d22.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWoz SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T001579 MSH
TERMUI T001582 MSH
TERMUI T001583 MSH
TERMUI T505746 MSH
TERMUI T505747 MSH
TERMUI T505760 MSH
TERMUI T505761 MSH
TERMUI T771058 MSH
TH AU MSH
TH BAN (19XX) MSH
TH CA MSH
TH DE MSH
TH ES MSH
TH FDA SRS (2014) MSH
TH FR MSH
TH IE MSH
TH INN (19XX) MSH
TH MX MSH
TH NLM (1990) MSH
TH NLM (2003) MSH
TH NLM (2011) MSH
TH NL MSH
TH UK MSH
TH USAN (1973) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^671^Active/Master NDFRT
VANDF_RECORD 50.6^395^Active/Master NDFRT
VUID 4018074 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002333

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