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| Terms & Properties |
Concept Unique Identifier (CUI): C0002260
NCI Thesaurus Code: C226 (see NCI Thesaurus info)
Semantic Type: Amino Acid, Peptide, or Protein
Semantic Type: Pharmacologic Substance
NCIt Definition: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)
MSH Definition: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
PDQ Definition: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for active clinical trials using this agent. (NCI Thesaurus)
NCI-GLOSS Definition: A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.
CSP Definition: polyamine antagonist which reversibly inhibits DNA polymerase and irreversibly inhibits ornithine decarboxylase; used against bladder cancer, with potential applications in epilepsy and PCP withdrawal.
Synonyms & Abbreviations: (see Synonym Details)
| (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid |
| 2-(Difluoromethyl)-DL-ornithine |
| 2-Difluoromethylornithine |
| 25344 |
| 70052-12-9 |
| ?-difluoromethylornithine |
| alpha Difluoromethyl Ornithine |
| alpha Difluoromethylornithine |
| alpha-Difluoromethyl Ornithine |
| alpha-Difluoromethylornithine |
| D,L-alpha-Difluoromethylornithine |
| DFMO |
| difluoromethylornithine |
| Difluromethylornithine |
| DL alpha Difluoromethylornithine |
| DL-alpha-Difluoromethylornithine |
| Eflornithine (product) |
| Eflornithine (substance) |
| Eflornithine [Chemical/Ingredient] |
| eflornithine |
| Ornithine, 2-(difluoromethyl)- |
| Ornithine, alpha-Difluoromethyl |
External Source Codes:
| NCI Thesaurus Code | C226 (see NCI Thesaurus info) |
| CAS Registry Number | 70052-12-9 (see NLM ChemIDplus info) |
| CAS Registry Number | 67037-37-0 (see NLM ChemIDplus info) |
| FDA UNII Code | ZQN1G5V6SR |
| PDQ Closed Trial Search ID | 39754 |
| PDQ Open Trial Search ID | 39754 (check for NCI PDQ open clinical trial info) |
Other Properties:
| Name | Value | Source |
|---|---|---|
| Accepted_Therapeutic_Use_For | Hirsutism, facial; Trypanosoma brucei gambiense (sleeping sickness) infection | NCI |
| ACTIVE | 1 | SNOMEDCT_US |
| AQL | AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR | MSH |
| CASE_SIGNIFICANCE_ID | 900000000000020002 | SNOMEDCT_US |
| CHARACTERISTIC_TYPE_ID | 900000000000011006 | SNOMEDCT_US |
| CHEBI_ID | CHEBI:41948 | NCI |
| Chemical_Formula | C6H12F2N2O2 | NCI |
| Contributing_Source | CTRP | NCI |
| Contributing_Source | FDA | NCI |
| CTV3ID | XU2Bx | SNOMEDCT_US |
| CTV3ID | XUVwe | SNOMEDCT_US |
| DATE_LAST_MODIFIED | 2008-10-09 | PDQ |
| DC | 1 | MSH |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DID | 1372-4650 | CSP |
| DX | 19870101 | MSH |
| EFFECTIVE_TIME | 20020131 | SNOMEDCT_US |
| EFFECTIVE_TIME | 20020731 | SNOMEDCT_US |
| FDA_UNII_CODE | ZQN1G5V6SR | DRUGBANK |
| FDA_UNII_CODE | ZQN1G5V6SR | NDFRT |
| HN | 91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 | MSH |
| LEVEL | Ingredient | NDFRT |
| MDA | 19860603 | MSH |
| MESH_DEFINITION | An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway. | NDFRT |
| MESH_DUI | D000518 | NDFRT |
| MESH_NAME | Eflornithine | NDFRT |
| MESH_UI | M0000787 | NDFRT |
| MMR | 20160705 | MSH |
| MN | D12.125.068.665.340 | MSH |
| MN | D12.125.095.765.340 | MSH |
| MODIFIER_ID | 900000000000451002 | SNOMEDCT_US |
| NCI_THESAURUS_CODE | C226 | PDQ |
| NDFRT_KIND | DRUG_KIND | NDFRT |
| NDFRT_KIND | INGREDIENT_KIND | NDFRT |
| NUI | N0000006592 | NDFRT |
| NUI | N0000021586 | NDFRT |
| OL | use EFLORNITHINE to search ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 | MSH |
| ORIG_STY | Drug/agent | PDQ |
| PA | D000970 | MSH |
| PA | D014344 | MSH |
| PA | D065108 | MSH |
| PID | 2415 | PDQ |
| PM | 91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 | MSH |
| RN | 0 | MSH |
| RN | ZQN1G5V6SR | MSH |
| RR | 4NH22NDW9H | MSH |
| RR | 67037-37-0 (Difluoromethylornithine) | MSH |
| RR | 70052-12-9 (Eflornithine) | MSH |
| RR | 96020-91-6 (mono-HCl, monohydrate) | MSH |
| RXAUI | 17748 | RXNORM |
| RXAUI | 2628014 | RXNORM |
| RXAUI | 3150130 | RXNORM |
| RXAUI | 3150131 | RXNORM |
| RXAUI | 3153291 | RXNORM |
| RXAUI | 3153295 | RXNORM |
| RXAUI | 3210731 | RXNORM |
| RXAUI | 3258377 | RXNORM |
| RXAUI | 3258378 | RXNORM |
| RXAUI | 6395357 | RXNORM |
| RXAUI | 6396221 | RXNORM |
| RXCUI | 569 | RXNORM |
| SNOMEDID | C-56112 | SNOMEDCT_US |
| SNOMEDID | F-615B4 | SNOMEDCT_US |
| SPL_SET_ID | a2c3d206-b893-4f65-a2f6-c11fa9a0e486 | MTHSPL |
| SPL_SET_ID | e872db73-7cd7-4886-9b0f-6710700e3765 | MTHSPL |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~XU2Bx | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~XUVwe | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000498005~MAPTARGET~C-56112 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000498005~MAPTARGET~F-615B4 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| TERMUI | T001542 | MSH |
| TERMUI | T001543 | MSH |
| TERMUI | T001545 | MSH |
| TERMUI | T001548 | MSH |
| TERMUI | T429688 | MSH |
| TH | BAN (19XX) | MSH |
| TH | FDA SRS (2014) | MSH |
| TH | INN (19XX) | MSH |
| TH | NLM (1991) | MSH |
| TH | NLM (2002) | MSH |
| TH | UNK (19XX) | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
| VANDF_RECORD | 50.6^2751^Active/Master | NDFRT |
| VUID | 4023581 | NDFRT |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002260
