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Terms & Properties

Concept Unique Identifier (CUI): C0002260

NCI Thesaurus Code: C226 (see NCI Thesaurus info)

Semantic Type: Amino Acid, Peptide, or Protein

Semantic Type: Pharmacologic Substance

NCIt Definition: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)

MSH Definition: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.

PDQ Definition: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.

CSP Definition: polyamine antagonist which reversibly inhibits DNA polymerase and irreversibly inhibits ornithine decarboxylase; used against bladder cancer, with potential applications in epilepsy and PCP withdrawal.

Synonyms & Abbreviations: (see Synonym Details)

(RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid

2-(Difluoromethyl)-DL-ornithine

2-Difluoromethylornithine

25344

70052-12-9

alpha Difluoromethyl Ornithine

alpha Difluoromethylornithine

alpha-Difluoromethyl Ornithine

alpha-Difluoromethylornithine

D,L-alpha-Difluoromethylornithine

DFMO

difluoromethylornithine

Difluromethylornithine

DL alpha Difluoromethylornithine

DL-alpha-Difluoromethylornithine

Eflornithine (substance)

Eflornithine [Chemical/Ingredient]

eflornithine

Ornithine, 2-(difluoromethyl)-

Ornithine, alpha-Difluoromethyl

Product containing eflornithine (medicinal product)

Product containing eflornithine

α-difluoromethylornithine

(RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid
2-(Difluoromethyl)-DL-ornithine
2-Difluoromethylornithine
25344
70052-12-9
alpha Difluoromethyl Ornithine
alpha Difluoromethylornithine
alpha-Difluoromethyl Ornithine
alpha-Difluoromethylornithine
D,L-alpha-Difluoromethylornithine
DFMO
difluoromethylornithine
Difluromethylornithine
DL alpha Difluoromethylornithine
DL-alpha-Difluoromethylornithine
Eflornithine (substance)
Eflornithine [Chemical/Ingredient]
eflornithine
Ornithine, 2-(difluoromethyl)-
Ornithine, alpha-Difluoromethyl
Product containing eflornithine (medicinal product)
Product containing eflornithine
α-difluoromethylornithine

External Source Codes:

NCI Thesaurus Code C226 (see NCI Thesaurus info)

CAS Registry Number 70052-12-9 (see NLM ChemIDplus info)

CAS Registry Number 67037-37-0 (see NLM ChemIDplus info)

FDA UNII Code ZQN1G5V6SR

PDQ Closed Trial Search ID 39754

PDQ Open Trial Search ID 39754 (check for NCI PDQ open clinical trial info)

NCI Thesaurus Code	C226 (see NCI Thesaurus info)
CAS Registry Number	70052-12-9 (see NLM ChemIDplus info)
CAS Registry Number	67037-37-0 (see NLM ChemIDplus info)
FDA UNII Code	ZQN1G5V6SR
PDQ Closed Trial Search ID	39754
PDQ Open Trial Search ID	39754 (check for NCI PDQ open clinical trial info)

Other Properties:

Name Value Source
Accepted_Therapeutic_Use_For Hirsutism, facial; Trypanosoma brucei gambiense (sleeping sickness) infection NCI

ACTIVE 1 SNOMEDCT_US

AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH

CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US

CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US

CHEBI_ID CHEBI:41948 NCI

Chemical_Formula C6H12F2N2O2 NCI

Contributing_Source CTRP NCI

Contributing_Source FDA NCI

CTV3ID XU2Bx SNOMEDCT_US

CTV3ID XUVwe SNOMEDCT_US

DATE_LAST_MODIFIED 2008-10-09 PDQ

DC 1 MSH

DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US

DID 1372-4650 CSP

DX 19870101 MSH

EFFECTIVE_TIME 20020131 SNOMEDCT_US

EFFECTIVE_TIME 20020731 SNOMEDCT_US

FDA_UNII_CODE ZQN1G5V6SR DRUGBANK

FDA_UNII_CODE ZQN1G5V6SR NDFRT

HN 91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 MSH

LEVEL Ingredient NDFRT

MDA 19860603 MSH

MESH_DEFINITION An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway. NDFRT

MESH_DUI D000518 NDFRT

MESH_NAME Eflornithine NDFRT

MESH_UI M0000787 NDFRT

MMR 20160705 MSH

MN D12.125.068.665.340 MSH

MN D12.125.095.765.340 MSH

MODIFIER_ID 900000000000451002 SNOMEDCT_US

NCI_THESAURUS_CODE C226 PDQ

NDFRT_KIND DRUG_KIND NDFRT

NDFRT_KIND INGREDIENT_KIND NDFRT

NUI N0000006592 NDFRT

NUI N0000021586 NDFRT

OL use EFLORNITHINE to search ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 MSH

ORIG_STY Drug/agent PDQ

PA D000970 MSH

PA D014344 MSH

PA D065108 MSH

PID 2415 PDQ

PM 91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 MSH

RN 0 MSH

RN ZQN1G5V6SR MSH

RR 4NH22NDW9H MSH

RR 67037-37-0 (Difluoromethylornithine) MSH

RR 70052-12-9 (Eflornithine) MSH

RR 96020-91-6 (mono-HCl, monohydrate) MSH

RXAUI 17748 RXNORM

RXAUI 2628014 RXNORM

RXAUI 3150130 RXNORM

RXAUI 3150131 RXNORM

RXAUI 3153291 RXNORM

RXAUI 3153295 RXNORM

RXAUI 3210731 RXNORM

RXAUI 3258377 RXNORM

RXAUI 3258378 RXNORM

RXAUI 6395357 RXNORM

RXAUI 6396221 RXNORM

RXCUI 569 RXNORM

SPL_SET_ID a2c3d206-b893-4f65-a2f6-c11fa9a0e486 MTHSPL

SPL_SET_ID e872db73-7cd7-4886-9b0f-6710700e3765 MTHSPL

SUBSET_MEMBER 900000000000497000~MAPTARGET~XU2Bx SNOMEDCT_US

SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVwe SNOMEDCT_US

SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US

SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US

SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US

SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US

TERMUI T001542 MSH

TERMUI T001543 MSH

TERMUI T001545 MSH

TERMUI T001548 MSH

TERMUI T429688 MSH

TH BAN (19XX) MSH

TH FDA SRS (2014) MSH

TH INN (19XX) MSH

TH NLM (1991) MSH

TH NLM (2002) MSH

TH UNK (19XX) MSH

TYPE_ID 900000000000003001 SNOMEDCT_US

TYPE_ID 900000000000013009 SNOMEDCT_US

VANDF_RECORD 50.6^2751^Active/Master NDFRT

VUID 4023581 NDFRT

Name	Value	Source
Accepted_Therapeutic_Use_For	Hirsutism, facial; Trypanosoma brucei gambiense (sleeping sickness) infection	NCI
ACTIVE	1	SNOMEDCT_US
AQL	AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR	MSH
CASE_SIGNIFICANCE_ID	900000000000448009	SNOMEDCT_US
CHARACTERISTIC_TYPE_ID	900000000000011006	SNOMEDCT_US
CHEBI_ID	CHEBI:41948	NCI
Chemical_Formula	C6H12F2N2O2	NCI
Contributing_Source	CTRP	NCI
Contributing_Source	FDA	NCI
CTV3ID	XU2Bx	SNOMEDCT_US
CTV3ID	XUVwe	SNOMEDCT_US
DATE_LAST_MODIFIED	2008-10-09	PDQ
DC	1	MSH
DEFINITION_STATUS_ID	900000000000074008	SNOMEDCT_US
DID	1372-4650	CSP
DX	19870101	MSH
EFFECTIVE_TIME	20020131	SNOMEDCT_US
EFFECTIVE_TIME	20020731	SNOMEDCT_US
FDA_UNII_CODE	ZQN1G5V6SR	DRUGBANK
FDA_UNII_CODE	ZQN1G5V6SR	NDFRT
HN	91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90	MSH
LEVEL	Ingredient	NDFRT
MDA	19860603	MSH
MESH_DEFINITION	An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.	NDFRT
MESH_DUI	D000518	NDFRT
MESH_NAME	Eflornithine	NDFRT
MESH_UI	M0000787	NDFRT
MMR	20160705	MSH
MN	D12.125.068.665.340	MSH
MN	D12.125.095.765.340	MSH
MODIFIER_ID	900000000000451002	SNOMEDCT_US
NCI_THESAURUS_CODE	C226	PDQ
NDFRT_KIND	DRUG_KIND	NDFRT
NDFRT_KIND	INGREDIENT_KIND	NDFRT
NUI	N0000006592	NDFRT
NUI	N0000021586	NDFRT
OL	use EFLORNITHINE to search ALPHA-DIFLUOROMETHYLORNITHINE 1987-90	MSH
ORIG_STY	Drug/agent	PDQ
PA	D000970	MSH
PA	D014344	MSH
PA	D065108	MSH
PID	2415	PDQ
PM	91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90	MSH
RN	0	MSH
RN	ZQN1G5V6SR	MSH
RR	4NH22NDW9H	MSH
RR	67037-37-0 (Difluoromethylornithine)	MSH
RR	70052-12-9 (Eflornithine)	MSH
RR	96020-91-6 (mono-HCl, monohydrate)	MSH
RXAUI	17748	RXNORM
RXAUI	2628014	RXNORM
RXAUI	3150130	RXNORM
RXAUI	3150131	RXNORM
RXAUI	3153291	RXNORM
RXAUI	3153295	RXNORM
RXAUI	3210731	RXNORM
RXAUI	3258377	RXNORM
RXAUI	3258378	RXNORM
RXAUI	6395357	RXNORM
RXAUI	6396221	RXNORM
RXCUI	569	RXNORM
SPL_SET_ID	a2c3d206-b893-4f65-a2f6-c11fa9a0e486	MTHSPL
SPL_SET_ID	e872db73-7cd7-4886-9b0f-6710700e3765	MTHSPL
SUBSET_MEMBER	900000000000497000~MAPTARGET~XU2Bx	SNOMEDCT_US
SUBSET_MEMBER	900000000000497000~MAPTARGET~XUVwe	SNOMEDCT_US
SUBSET_MEMBER	900000000000508004~ACCEPTABILITYID~900000000000548007	SNOMEDCT_US
SUBSET_MEMBER	900000000000508004~ACCEPTABILITYID~900000000000549004	SNOMEDCT_US
SUBSET_MEMBER	900000000000509007~ACCEPTABILITYID~900000000000548007	SNOMEDCT_US
SUBSET_MEMBER	900000000000509007~ACCEPTABILITYID~900000000000549004	SNOMEDCT_US
TERMUI	T001542	MSH
TERMUI	T001543	MSH
TERMUI	T001545	MSH
TERMUI	T001548	MSH
TERMUI	T429688	MSH
TH	BAN (19XX)	MSH
TH	FDA SRS (2014)	MSH
TH	INN (19XX)	MSH
TH	NLM (1991)	MSH
TH	NLM (2002)	MSH
TH	UNK (19XX)	MSH
TYPE_ID	900000000000003001	SNOMEDCT_US
TYPE_ID	900000000000013009	SNOMEDCT_US
VANDF_RECORD	50.6^2751^Active/Master	NDFRT
VUID	4023581	NDFRT

Additional Concept Data: (none)

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