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Allopurinol (CUI C0002144) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0002144

NCI Thesaurus Code: C224  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)

PDQ Definition: A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug that lowers high levels of uric acid (a byproduct of metabolism) in the blood caused by some cancer treatments.

CSP Definition: drug used to treat gout and other conditions in which there is an excessive buildup of uric acid.

MSH Definition: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.

Synonyms & Abbreviations: (see Synonym Details)
1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one
1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidine-4-one
1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one
1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
1H-Pyrazolo(3,4-D)pyrimidin-4-ol
1H-Pyrazolo[3,4-d]pyrimidin-4-ol
4'-HPP
4'-Hydroxypyrazolol(3,4-D)pyrimidine
4-HPP
4-Hydroxy-1H-pyrazolo(3,4-D)pyrimidine
4-Hydroxy-3,4-pyrazolopyrimidine
4-Hydroxypyrazolo(3,4-D)pyrimidine
4-Hydroxypyrazolo[3,4-d]pyrimidine
4-Hydroxypyrazolopyrimidine
4-Hydroxypyrazolyl(3,4-D)pyrimidine
4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-
4H-Pyrazolo(3,4-D)pyrimidin-4-one
AL-100
Allopurinol (product)
Allopurinol (substance)
Allopurinol [Chemical/Ingredient]
Allopurinolum
allopurinol
ALLO
Alopurinol
Lopurin
Sigapurol
Zurinol

External Source Codes: 
NCI Thesaurus Code C224 (see NCI Thesaurus info)
CAS Registry Number 315-30-0 (see NLM ChemIDplus info)
FDA UNII Code 63CZ7GJN5I
NSC Code 101655 (see NCI DTP info)
NSC Code 1390 (see NCI DTP info)
PDQ Closed Trial Search ID 38452
PDQ Open Trial Search ID 38452 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:40279 NCI
Chemical_Formula C5H4N4O NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID j61.. SNOMEDCT_US
CTV3ID XUWrT SNOMEDCT_US
DATE_LAST_MODIFIED 2016-01-13 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0875-2372 CSP
DX 19680101 MSH
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20060731 SNOMEDCT_US
FDA_UNII_CODE 63CZ7GJN5I DRUGBANK
FDA_UNII_CODE 63CZ7GJN5I NDFRT
HN 68(67) MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms. NDFRT
MESH_DUI D000493 NDFRT
MESH_NAME Allopurinol NDFRT
MESH_UI M0000745 NDFRT
MMR 20160701 MSH
MN D03.633.100.759.160 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C224 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005830 NDFRT
NUI N0000146247 NDFRT
ORIG_STY Drug/agent PDQ
PA D000963 MSH
PA D004791 MSH
PA D006074 MSH
PA D016166 MSH
PID 1107 PDQ
PM 68 MSH
RN 63CZ7GJN5I MSH
RR 315-30-0 (Allopurinol) MSH
RXAUI 16710 RXNORM
RXAUI 2067669 RXNORM
RXAUI 2621244 RXNORM
RXAUI 2622157 RXNORM
RXAUI 3033081 RXNORM
RXAUI 3093810 RXNORM
RXAUI 3098377 RXNORM
RXAUI 3098378 RXNORM
RXAUI 3107765 RXNORM
RXAUI 3107766 RXNORM
RXCUI 519 RXNORM
SID APRD00435 DRUGBANK
SID DB03027 DRUGBANK
SNOMEDID C-B7020 SNOMEDCT_US
SNOMEDID F-61A1C SNOMEDCT_US
SPL_SET_ID 0ad457ac-d459-4df9-8cba-e14bf794c917 MTHSPL
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SPL_SET_ID 682dd8b8-fc6e-47c5-95b7-82d7ad96b750 MTHSPL
SPL_SET_ID 6bbb8947-4f93-4f2a-b205-f4594908aecc MTHSPL
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SPL_SET_ID fd8f8b8b-f25e-46e9-969a-65363b66e09b MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~j61.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWrT SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-B7020 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-61A1C SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T001451 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH JAN (19XX) MSH
TH USAN (1964) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^490^Active/Master NDFRT
VANDF_RECORD 50.6^245^Active/Master NDFRT
VUID 4017895 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0002144

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