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Primary Myelofibrosis (CUI C0001815) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0001815

NCI Thesaurus Code: C2862  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis. (WHO, 2001)

PDQ Definition: A chronic myeloproliferative disorder characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis. The cause is unknown. The median survival time is 3-5 years from diagnosis. (WHO, 2001) Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia.

CTEP Definition: CTEP_For_FDA: 10028537/Myelofibrosis

MSH Definition: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.

Synonyms & Abbreviations: (see Synonym Details)
Agnogenic myeloid metaplasia
Agnogenic Myeloid Metaplasias
Aleukemic myelosis
AMM
Bone Marrow Fibroses
BONE MARROW FIBROSIS
Chronic idiopathic myelofibrosis
CIMF
Fibroses, Bone Marrow
Fibrosis, Bone Marrow
Idiopathic Bone Marrow Fibrosis
Idiopathic myelofibrosis
Idiopathic myelofibrosis (chronic)
Megakaryocytic myelosclerosis
Metaplasia, Agnogenic Myeloid
Metaplasia, Myeloid
Metaplasias, Agnogenic Myeloid
Metaplasias, Myeloid
METAPLASIA MYELOID
MOS
Myelofibroses, Primary
Myelofibrosis
Myelofibrosis, Primary
myelofibrosis/sclerosis with myeloid metaplasia (MMM)
MYELOFIBROSIS AND MYELOID METAPLASIA
Myelofibrosis as a result of myeloproliferative disease
Myelofibrosis with myeloid metaplasia
Myelofibrosis with myelometaplasia
Myelofi w myelo metaplas
Myeloid Metaplasia
MYELOID METAPLASIA, AGNOGENIC
Myeloid Metaplasias
Myeloid Metaplasias, Agnogenic
Myeloid metaplasia (disorder)
Myeloid metaplasia (morphologic abnormality)
MYELOID METAPLASIA <PRIMARY MYELOFIBROSIS>
Myeloscleroses
MYELOSCLEROSIS
Myelosclerosis with myeloid metaplasia
Myelosclerosis with myeloid metaplasia (disorder)
Myelosclerosis with myeloid metaplasia (morphologic abnormality)
Myeloses, Nonleukemic
MYELOSIS, ALEUKEMIC
Myelosis, Nonleukemic
Myelosis-non-leukaemic
Myelosis-non-leukemic
Myelosis non-leukaemic
Myelosis non-leukemic
MYELOSIS NONLEUKEMIC
Nonleukemic Myeloses
Nonleukemic Myelosis
Primary Myelofibroses
Primary myelofibrosis
Primary Myelofibrosis [Disease/Finding]

External Source Codes: 
NCI Thesaurus Code C2862 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTEP NCI
Contributing_Source CTRP NCI
CTV3ID BBs3. SNOMEDCT_US
CTV3ID XaBBt SNOMEDCT_US
CTV3ID XUjNo SNOMEDCT_US
CTV3ID XULje SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2011-06-03 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DISEASE_IDENTIFIER_ID 19637 GARD
DISEASE_IDENTIFIER_ID 19638 GARD
DISEASE_IDENTIFIER_ID 19639 GARD
DISEASE_IDENTIFIER_ID 19640 GARD
DISEASE_IDENTIFIER_ID 34152 GARD
DISEASE_IDENTIFIER_ID 34153 GARD
DX 20090101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
EFFECTIVE_TIME 20100131 SNOMEDCT_US
HN 2009 MSH
ICD-O-3_Code 9961/3 NCI
ICD-O-3_CODE 9961/3 SNOMEDCT_US
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
MDA 20080708 MSH
MESH_DEFINITION A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone. NDFRT
MESH_DUI D055728 NDFRT
MESH_NAME Primary Myelofibrosis NDFRT
MESH_UI M0519745 NDFRT
MMR 20130708 MSH
MN C15.378.190.636.765 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C2862 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NUI N0000181011 NDFRT
ORIG_STY Cancer stage PDQ
PID 1993 PDQ
PM 2009; see MYELOID METAPLASIA or MYELOFIBROSIS 1975-2008 MSH
PRIMARY_PATH 10028561$10028578$10018865$10029104$Myeloid metaplasia$Myeloproliferative disorders (excl leukaemias)$Haematopoietic neoplasms (excl leukaemias and lymphomas)$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_PATH 10077161$10028578$10018865$10029104$Primary myelofibrosis$Myeloproliferative disorders (excl leukaemias)$Haematopoietic neoplasms (excl leukaemias and lymphomas)$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3286650 RXNORM
RXAUI 3286807 RXNORM
RXAUI 3287271 RXNORM
RXAUI 3288083 RXNORM
RXAUI 3288086 RXNORM
RXAUI 3288087 RXNORM
RXAUI 3288461 RXNORM
RXAUI 3288462 RXNORM
RXAUI 5039662 RXNORM
RXAUI 5930570 RXNORM
RXAUI 5931241 RXNORM
RXCUI 1002146 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 17.1 MDR
SMQ_TERM_ADDVERSION 18.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_LMVERSION 17.1 MDR
SMQ_TERM_LMVERSION 18.0 MDR
SMQ_TERM_LMVERSION 18.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMEDID DC-00121 SNOMEDCT_US
SNOMEDID DF-00B9C SNOMEDCT_US
SNOMEDID M-73500 SNOMEDCT_US
SNOMEDID M-99613 SNOMEDCT_US
SOS Excludes: myelofibrosis NOS (289.83); myelophthisic anemia (284.2); myelophthisis (284.2); secondary myelofibrosis (289.83) ICD9CM
SUBSET_MEMBER 446608001~MAPTARGET~9961/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D47.1 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D73.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D47.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D73.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D47.4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D73.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D47.4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D73.1 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBs3. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XaBBt SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUjNo SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XULje SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-00121 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DF-00B9C SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-73500 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-99613 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T027416 MSH
TERMUI T027417 MSH
TERMUI T027418 MSH
TERMUI T027419 MSH
TERMUI T027423 MSH
TERMUI T027424 MSH
TERMUI T027425 MSH
TERMUI T716894 MSH
TERMUI T811406 MSH
TERMUI T842320 MSH
TERMUI T842321 MSH
TH GHR (2014) MSH
TH NLM (1964) MSH
TH NLM (1966) MSH
TH NLM (2009) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0001815

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