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Addison Disease (CUI C0001403) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0001403

NCI Thesaurus Code: C26689  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A long-standing and persistent diminished production of adrenocortical hormones due to a disorder originating within the adrenal glands.

GARD Definition: Addison's disease is a condition that occurs when the adrenal glands do not produce enough of their hormones. This condition can be caused by damage to the adrenal glands, autoimmune conditions, and certain genetic conditions. Some of the symptoms include changes in blood pressure, chronic diarrhea, darkening of the skin, paleness, extreme weakness, fatigue, nausea and vomiting, salt craving, and weight loss. Treatment with replacement corticosteroids usually controls the symptoms. - this information is from GARD/ORDR/NCATS.

HPO Definition: Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves. [HPO:probinson]

MEDLINEPLUS Definition: 

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.

Symptoms include

  • Weight loss
  • Muscle weakness
  • Fatigue that gets worse over time
  • Low blood pressure
  • Patchy or dark skin

Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

NICHD Definition: The diminished production of adrenocortical hormones due to a pathologic process within the adrenal glands.

CSP Definition: disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin; due to tuberculosis or autoimmune induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol.

MSH Definition: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.

Synonyms & Abbreviations: (see Synonym Details)
Addison Disease [Disease/Finding]
ADDISON DISEASE
ADDISON DIS
Addison's disease (disorder)
Addison's disease NOS
Addison's disease
Addisons Disease
ADDISONS DIS
Adrenal insufficiency (Addison disease)
ADRENAL INSUFFICIENCY (ADDISON'S DISEASE)
ADRENAL INSUFFICIENCY, CHRONIC
Adrenal Insufficiency, Primary
Adrenocortical Insufficiencies, Primary
Adrenocortical insufficiency chronic
ADRENOCORTICAL INSUFFICIENCY, CHRONIC
ADRENOCORTICAL INSUFFICIENCY, PRIMARY FAILURE
Adrenocortical Insufficiency, Primary
Chronic Primary Adrenal Insufficiency
Classic Addisons disease
DISEASE ADDISON'S
Disease, Addison
Hypoadrenalism, Primary
Hypoadrenalisms, Primary
Hypocortisolism
Insufficiencies, Primary Adrenocortical
Insufficiency, Primary Adrenocortical
Primary Addisons disease
Primary adrenal insufficiency
Primary adrenocortical failure
Primary Adrenocortical Insufficiencies
Primary adrenocortical insufficiency (disorder)
Primary adrenocortical insufficiency
Primary hypoadrenalism

External Source Codes: 
NCI Thesaurus Code C26689 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
ANSWER_CODE 10 LNC
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID C1541 SNOMEDCT_US
CTV3ID XUWM8 SNOMEDCT_US
DATE_CREATED 08/24/2000 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0060-3321 CSP
DISEASE_IDENTIFIER_ID 17038 GARD
DISEASE_IDENTIFIER_ID 34221 GARD
DISEASE_IDENTIFIER_ID 34222 GARD
DX 19600101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EXCLUDES1 Addison only phenotype adrenoleukodystrophy (E71.528) ICD10CM
EXCLUDES1 amyloidosis (E85.-) ICD10CM
EXCLUDES1 tuberculous Addison's disease (A18.7) ICD10CM
EXCLUDES1 Waterhouse-Friderichsen syndrome (A39.1) ICD10CM
EXTERNALLY_DEFINED N LNC
HAS_GARD_PAGE true GARD
HN 2005 (1963) MSH
HPO_COMMENT Deficiency of both glucocorticoids and mineralocorticoids. HPO
IAN DEFAULT ICD10
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Addison's disease ICD10
INCLUSION_TERM Autoimmune adrenalitis ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-11-06T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES. NDFRT
MESH_DUI D000224 NDFRT
MESH_NAME Addison Disease NDFRT
MESH_UI M0000346 NDFRT
MMR 20120703 MSH
MN C19.053.500.263 MSH
MN C20.111.163 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/addisondisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/addisondisease.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Addison Disease NCI
NUI N0000000305 NDFRT
ORDER_NO 04337 ICD10CM
PM 2005; see ADDISON'S DISEASE 1966-2004 MSH
PRIMARY_PATH 10001130$10001343$10001353$10014698$Addison's disease$Adrenal cortical hypofunctions$Adrenal gland disorders$Endocrine disorders MDR
PRIMARY_PATH 10052381$10001343$10001353$10014698$Primary adrenal insufficiency$Adrenal cortical hypofunctions$Adrenal gland disorders$Endocrine disorders MDR
PRIMARY_SOC 10014698 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5740/addisons-disease/resources/1 GARD
RXAUI 3106289 RXNORM
RXAUI 3106290 RXNORM
RXAUI 3106292 RXNORM
RXAUI 3223565 RXNORM
RXAUI 3223567 RXNORM
RXAUI 3223620 RXNORM
RXCUI 1023821 RXNORM
SID HP:0000862 HPO
SID HP:0008219 HPO
SID HP:0008252 HPO
SNOMED_CID 363732003 NDFRT
SNOMED_CID 373662000 NDFRT
SNOMEDID DB-70608 SNOMEDCT_US
SNOMEDID DB-70620 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E27.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E27.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E27.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ADDISON'S DISEASE WITH ADRENOLEUCODYSTROPHY CHOOSE E71.528 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF POLYGLANDULAR AUTOIMMUNE SYNDROME, TYPE 1 CHOOSE E31.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF TUBERCULOUS ADDISON'S DISEASE CHOOSE A18.7 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 11244009 | Polyglandular autoimmune syndrome, type 1 (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 186270000 | Tuberculous Addison's disease (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 237760008 | Addison's disease with adrenoleucodystrophy (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A18.7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E27.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E31.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E71.528 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~C1541 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWM8 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DB-70608 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DB-70620 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T000660 MSH
TERMUI T000661 MSH
TERMUI T573076 MSH
TERMUI T573119 MSH
TERMUI T573120 MSH
TH NLM (1963) MSH
TH NLM (2005) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0001403

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