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Acromegaly (CUI C0001206) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0001206

NCI Thesaurus Code: C84533  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A syndrome characterized by enlargement of the hands, feet, ears, nose, lips, and tongue, skin thickening and swelling of internal organs. It is caused by overproduction of growth hormone in the pituitary gland, usually by a pituitary adenoma.

GARD Definition: Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritiscarpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly. - this information is from GARD/ORDR/NCATS.

NCI-GLOSS Definition: A condition in which the pituitary gland makes too much growth hormone after normal growth of the skeleton is finished. This causes the bones of the hands, feet, head, and face to grow larger than normal. Acromegaly can be caused by a pituitary gland tumor.

NICHD Definition: Excessive growth of body tissues due to overproduction of growth hormone in an individual who has completed linear growth.

CSP Definition: disorder caused by excessive secretion of somatotropin, characterized by bony enlargement of face, hands, feet, head and thorax.

MSH Definition: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)

Synonyms & Abbreviations: (see Synonym Details)
Acromegalia
Acromegaly (disorder)
Acromegaly [Disease/Finding]
acromegaly
anterior pituitary adenoma syndrome
growth hormone hypersecretion syndrome
Hypersecretion Syndrome, Somatotropin (Acromegaly)
Hypersecretion Syndromes, Somatotropin (Acromegaly)
INAPPROPRIATE GH SECRET SYNDROME ACROMEGALY
Inappropriate GH Secretion Syndrome (Acromegaly)
INAPPROPRIATE GROWTH HORMONE SECRET SYNDROME ACROMEGALY
Inappropriate Growth Hormone Secretion Syndrome (Acromegaly)
Marie disease
SOMATOTROPIN HYPERSECRET SYNDROME ACROMEGALY
Somatotropin Hypersecretion Syndrome (Acromegaly)
Somatotropin Hypersecretion Syndromes (Acromegaly)
STH hypersecretion syndrome
Syndrome, Somatotropin Hypersecretion (Acromegaly)
Syndromes, Somatotropin Hypersecretion (Acromegaly)

External Source Codes: 
NCI Thesaurus Code C84533 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate with GROWTH HORMONE/secret in animals or HUMAN GROWTH HORMONE/secret in humans if pertinent MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID C1302 SNOMEDCT_US
DATE_LAST_MODIFIED 10/09/2014 RADLEX
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2335-8651 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_CHANGES_TO_CLASS obs RADLEX
LAST_REVIEW_DATE 2009-01-19T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80) NDFRT
MESH_DUI D000172 NDFRT
MESH_NAME Acromegaly NDFRT
MESH_UI M0000261 NDFRT
MMR 20090706 MSH
MN C05.116.132.082 MSH
MN C10.228.140.617.738.250.100 MSH
MN C19.700.355.179 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Acromegaly NCI
NUI N0000000295 NDFRT
PRIMARY_PATH 10000599$10002700$10021112$10014698$Acromegaly$Anterior pituitary hyperfunction$Hypothalamus and pituitary gland disorders$Endocrine disorders MDR
PRIMARY_SOC 10014698 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5725/acromegaly/resources/1 GARD
REPLACED_BY RID46043 RADLEX
RXAUI 3105770 RXNORM
RXAUI 3105771 RXNORM
RXAUI 3178797 RXNORM
RXAUI 3178798 RXNORM
RXAUI 3239337 RXNORM
RXCUI 1025751 RXNORM
SNOMED_CID 74107003 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E22.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E22.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E22.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF X-LINKED INTELLECTUAL DISABILITY WITH ACROMEGALY AND HYPERACTIVITY SYNDROME CHOOSE F79 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF X-LINKED INTELLECTUAL DISABILITY WITH ACROMEGALY AND HYPERACTIVITY SYNDROME CHOOSE F90.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 719826004 | X-linked intellectual disability with acromegaly and hyperactivity syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E22.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F79 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F90.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~C1302 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_STATUS Retired RADLEX
TERMUI T000517 MSH
TERMUI T365908 MSH
TERMUI T365909 MSH
TERMUI T365910 MSH
TH NLM (1966) MSH
TH NLM (2000) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0001206

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