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Lactic Acidosis (CUI C0001125) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0001125

NCI Thesaurus Code: C98969  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Metabolic acidosis characterized by the accumulation of lactate in the body. It is caused by tissue hypoxia.

MSH Definition: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.

HPO Definition: An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids. [HPO:probinson]

CSP Definition: acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized; may occur spontaneously or in association with diseases such as diabetes mellitus, leukemia, or liver failure.

Synonyms & Abbreviations: (see Synonym Details)
ACIDOSIS LACTIC
Acidosis, Lactic [Disease/Finding]
Acidosis, Lactic
lactacidosis
Lactic acidosis (disorder)
lactic acidosis
Lacticacidosis

External Source Codes: 
NCI Thesaurus Code C98969 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID C3622 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1849-5394 CSP
DX 19870101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D065906 MSH
HN 87 MSH
HN Changed descriptor 2000; through 1999 use "lactacidosis." ETOH descriptor 2000. AOD
HPO_COMMENT Note that the term acidemia is used to describe the state of low pH in the blood, whereas acidosis is used to describe the processes that lead to acidemia. In medical jargon, however, the two terms are used interchangeably. HPO
MDA 19860418 MSH
MESH_DEFINITION Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE. NDFRT
MESH_DUI D000140 NDFRT
MESH_NAME Acidosis, Lactic NDFRT
MESH_UI M0000214 NDFRT
MMR 20140613 MSH
MN C18.452.076.176.180 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Lactic Acidosis NCI
NUI N0000000284 NDFRT
PM 87 MSH
PRIMARY_PATH 10023676$10027416$10000485$10027433$Lactic acidosis$Metabolic acidoses (excl diabetic acidoses)$Acid-base disorders$Metabolism and nutrition disorders MDR
PRIMARY_SOC 10027433 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3105422 RXNORM
RXAUI 3105423 RXNORM
RXAUI 3188039 RXNORM
RXCUI 1021823 RXNORM
SID HP:0003255 HPO
SID HP:0005960 HPO
SMQ_TERM_ADDVERSION 8.1 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 8.1 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 91273001 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E87.2 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E87.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E87.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P74.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF D-LACTIC ACIDOSIS AND IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P84 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DIHYDROLIPOAMIDE DEHYDROGENASE DEFICIENCY CHOOSE E71.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPERTROPHIC CARDIOMYOPATHY WITH HYPOTONIA AND LACTIC ACIDOSIS SYNDROME AND IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P84 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPERTROPHIC CARDIOMYOPATHY WITH HYPOTONIA AND LACTIC ACIDOSIS SYNDROME AND IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P94.2 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPERTROPHIC CARDIOMYOPATHY WITH HYPOTONIA AND LACTIC ACIDOSIS SYNDROME CHOOSE E87.2 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPERTROPHIC CARDIOMYOPATHY WITH HYPOTONIA AND LACTIC ACIDOSIS SYNDROME CHOOSE I42.2 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HYPERTROPHIC CARDIOMYOPATHY WITH HYPOTONIA AND LACTIC ACIDOSIS SYNDROME CHOOSE M62.89 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF INFANTILE ENCEPHALOPATHY AND LACTIC ACIDOSIS CHOOSE G93.49 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MITOCHONDRIAL MYOPATHY, LACTIC ACIDOSIS, DEAFNESS SYNDROME AND IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P74.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MITOCHONDRIAL MYOPATHY, LACTIC ACIDOSIS, DEAFNESS SYNDROME CHOOSE E87.2 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MITOCHONDRIAL MYOPATHY, LACTIC ACIDOSIS, DEAFNESS SYNDROME CHOOSE G71.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF MITOCHONDRIAL MYOPATHY, LACTIC ACIDOSIS, DEAFNESS SYNDROME CHOOSE H91.90 | CONSIDER LATERALITY SPECIFICATION | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY CHOOSE E74.4 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 13490001000004105 | D-lactic acidosis | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 29914000 | Dihydrolipoamide dehydrogenase deficiency | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 46683007 | Pyruvate dehydrogenase complex deficiency | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 718713000 | Hypertrophic cardiomyopathy with hypotonia and lactic acidosis syndrome | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 718713000 | Hypertrophic cardiomyopathy with hypotonia and lactic acidosis syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732951005 | Mitochondrial myopathy, lactic acidosis, deafness syndrome | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 732951005 | Mitochondrial myopathy, lactic acidosis, deafness syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 76938004 | Infantile encephalopathy AND lactic acidosis | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E71.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E74.4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E87.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G71.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G93.49 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~H91.90 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I42.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M62.89 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P74.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P84 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P94.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~C3622 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T000400 MSH
TERMUI T000401 MSH
TH NLM (1987) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0001125

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