|
|
|
|
|
| Terms & Properties |
Concept Unique Identifier (CUI): C1134696
NCI Thesaurus Code: C2688 (see NCI Thesaurus info)
Semantic Type: Pharmacologic Substance
Semantic Type: Organic Chemical
NCIt Definition: A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor.
PDQ Definition: A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor. (NCI Thesaurus)
NCI-GLOSS Definition: A drug used to treat breast cancer that has spread or that has come back within 6 months after chemotherapy. It is also being studied in the treatment of newly diagnosed breast cancer and other types of cancer. ABI-007 is a type of mitotic inhibitor.
Synonyms & Abbreviations: (see Synonym Details)
| 130-nm albumin-bound paclitaxel |
| ABI 007 |
| ABI-007 |
| ABI007 |
| Abraxane |
| Albumin-bound Paclitaxel |
| Albumin-Stabilized Nanoparticle Paclitaxel |
| nab paclitaxel |
| Nab-paclitaxel |
| Nanoparticle Albumin-bound Paclitaxel |
| Nanoparticle Paclitaxel |
| paclitaxel albumin-stabilized nanoparticle formulation |
| Paclitaxel Albumin |
| Paclitaxel nanoparticle albumin-bound |
| Paclitaxel Protein-Bound |
| Protein-bound Paclitaxel |
External Source Codes:
| NCI Thesaurus Code | C2688 (see NCI Thesaurus info) |
| PDQ Closed Trial Search ID | 38690 |
| PDQ Open Trial Search ID | 38690 |
Other Properties:
| Name | Value | Source |
|---|---|---|
| Accepted_Therapeutic_Use_For | Metastatic breast cancer | NCI |
| Contributing_Source | CTRP | NCI |
| Contributing_Source | GDC | NCI |
| Contributing_Source | HemOnc | NCI |
| DATE_LAST_MODIFIED | 2015-10-02 | PDQ |
| FR | 953 | MSH |
| HM | D000418 | MSH |
| HM | D017239 | MSH |
| LT | TRD | MSH |
| LT | TRD | MTH |
| LT | TRD | PDQ |
| MDA | 20070611 | MSH |
| NCI_Drug_Dictionary_ID | 38690 | NCI |
| NCI_THESAURUS_CODE | C2688 | PDQ |
| NSC_Number | 736631 | NCI |
| ORIG_STY | Drug/agent | PDQ |
| PID | 11348 | PDQ |
| RN | 0 | MSH |
| RXAUI | 2355797 | RXNORM |
| RXAUI | 8021858 | RXNORM |
| RXCUI | 589511 | RXNORM |
| RXN_BN_CARDINALITY | single | RXNORM |
| SC | 1 | MSH |
| SOS | enhances tumor radiocurability and therapeutic gain | MSH |
| SRC | Clin Cancer Res 2007 Mar 15;13(6):1868-74 | MSH |
| TERMUI | T522430 | MSH |
| TERMUI | T522431 | MSH |
| TERMUI | T628830 | MSH |
| TERMUI | T699564 | MSH |
| TERMUI | T699565 | MSH |
| TH | NLM (2002) | MSH |
| TH | NLM (2005) | MSH |
| TH | NLM (2007) | MSH |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C1134696
