Concept Unique Identifier (CUI): C0671771

Semantic Type: Amino Acid, Peptide, or Protein

Semantic Type: Receptor

MSH Definition: Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.

Synonyms & Abbreviations: (see Synonym Details)

NR1I2

Nuclear Receptor Subfamily 1, Group I, Member 2

Pregnane X Receptor

Steroid and Xenobiotic Receptor

Steroid X Receptor

SXR Receptor

External Source Codes:  (none)

Other Properties:

Name	Value	Source
AQL	AD AG AI AN BI BL CH CL DE DF GE HI IM IP ME PH RE TU UL	MSH
DC	1	MSH
DX	20190101	MSH
HN	2019 (1998)	MSH
MDA	20180709	MSH
MMR	20180228	MSH
MN	D12.776.826.750.075	MSH
MN	D12.776.930.778.175	MSH
PM	2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006	MSH
RN	0	MSH
TERMUI	T000938869	MSH
TERMUI	T000938870	MSH
TERMUI	T000938871	MSH
TERMUI	T000938872	MSH
TERMUI	T000940016	MSH
TERMUI	T000940017	MSH
TH	NLM (1998)	MSH
TH	NLM (2000)	MSH
TH	NLM (2006)	MSH
TH	NLM (2019)	MSH

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0671771