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HELLP Syndrome (CUI C0162739) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0162739

NCI Thesaurus Code: C84750  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.

GARD Definition: 

HELLP syndrome is a rare but serious illness in pregnancy. This condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). It can also start soon after the baby is delivered. HELLP stands for Hemolysis, Elevated Liver enzyme levels and a Low Platelet count. These problems are often found in women with this syndrome. These problems, along with the high blood pressure commonly found in association with HELLP syndrome, can lead to problems for both the mother and the baby.  Many cases of HELLP syndrome are associated with  preeclampsia or eclampsia.  The exact cause of HELLP syndrome remains unknown, making it difficult to determine which women will be affected.  Treatment may involve medication and/or delivery of the baby.    
- this information is from GARD/ORDR/NCATS.

NICHD Definition: Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.

MSH Definition: A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.

Synonyms & Abbreviations: (see Synonym Details)
Haemolysis-elevated liver enzymes-low platelet count syndrome
HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome
HELLP - Syndrome of haemolysis, elevated liver enzymes and low platelet
HELLP - Syndrome of hemolysis, elevated liver enzymes and low platelet
HELLP syndrome (hemolysis, elevated liver enzymes, low platelets)
HELLP syndrome
HELLP
HEMOLYSIS, ELEVATED LIVER ENZYMES, AND LOW PLATELET COUNT
Hemolysis, Elevated Liver Enzymes, Lowered Platelets
Hemolysis-elevated liver enzymes-low platelet count syndrome (disorder)
Hemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome
Syndrome, HELLP

External Source Codes: 
NCI Thesaurus Code C84750 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL DG DH DI DT EC EH EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID X40C3 SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DISEASE_IDENTIFIER_ID 19097 GARD
DX 19930101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 93 MSH
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19920518 MSH
MMR 20210630 MSH
MN C12.050.703.395.186 MSH
ORDER_NO 25713 ICD10CM
PM 93 MSH
PRIMARY_PATH 10049058$10020776$10026908$10036585$HELLP syndrome$Hypertension associated disorders of pregnancy$Maternal complications of pregnancy$Pregnancy, puerperium and perinatal conditions MDR
PRIMARY_SOC 10036585 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 21.0 MDR
PT_IN_VERSION 21.1 MDR
PT_IN_VERSION 22.0 MDR
PT_IN_VERSION 22.1 MDR
PT_IN_VERSION 23.0 MDR
PT_IN_VERSION 23.1 MDR
PT_IN_VERSION 24.0 MDR
PT_IN_VERSION 24.1 MDR
PT_IN_VERSION 25.0 MDR
PT_IN_VERSION 25.1 MDR
PT_IN_VERSION 26.0 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/8528/hellp-syndrome/resources/1 GARD
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_ADDVERSION 14.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SUBSET_MEMBER 900000000000497000~MAPTARGET~X40C3 SNOMEDCT_US
TERMUI T051896 MSH
TERMUI T727248 MSH
TH NLM (1993) MSH
TH NLM (2011) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0162739

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