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| Terms & Properties |
Concept Unique Identifier (CUI): C0108779
NCI Thesaurus Code: C38897 (see NCI Thesaurus info)
Semantic Type: Amino Acid, Peptide, or Protein
Semantic Type: Immunologic Factor
NCIt Definition: A protein complex comprised of one T-cell surface glycoprotein CD3 delta chain (CD3D), one T-cell surface glycoprotein CD3 gamma chain (CD3G) and two T-cell surface glycoprotein CD3 epsilon chains (CD3E). CD3D, CD3G and CD3E are transmembrane proteins with one extracellular immunoglobulin domain and one intracellular ITAM domain. The CD3 complex is a T-cell co-receptor that noncovalently associates with either the disulfide bound heterodimeric alpha/beta T-cell receptor (TCR) or gamma/delta TCR and two copies of the accessory protein, T-cell surface glycoprotein CD3 zeta chain (CD247), which is a transmembrane protein with three ITAM domains. The TCR moiety of the TCR-CD3 complex binds to MHC and processed antigens on antigen presenting cells, which triggers phosphorylation of and cellular propagation of the signal by CD247 and the CD3 complex.
MSH Definition: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
CSP Definition: T-lymphocyte marker that functions as a molecular bridge holding the T-cell antigen receptor to the cell surface, and coupling antigen- TCR binding to T-cell activation events.
Synonyms & Abbreviations: (see Synonym Details)
| Antigen, CD3 |
| Antigen, T3 |
| ANTIGENS CD 003 |
| Antigens, CD3 |
| Antigens, T3 |
| CD 003 ANTIGENS |
| CD 003 COMPLEX |
| CD3 - Cluster of differentiation antigen 3 |
| CD3 Ag |
| CD3 Antigens |
| CD3 Antigen |
| CD3 Complex |
| CD3 molecule |
| CD3 |
| Cluster of differentiation antigen 3 |
| Cytoplasmic CD3 antigen |
| Leucocyte 4 |
| Leukocyte 4 |
| Lymphocyte antigen CD3 (substance) |
| Lymphocyte antigen CD3 |
| Lymphocyte antigen CyCD3 |
| OKT3 - Ortho Kung T3 |
| OKT3 antigen |
| Ortho Kung T3 |
| Pan T-cell marker |
| T AAA ANTIGENS 03 |
| T-cell lineage 3 |
| T-Cell Surface Glycoprotein CD3 |
| T3 - T-cell lineage 3 |
| T3 Antigens |
| T3 Antigen |
| T3 Complex |
| T3 molecule |
| UCHT-1 - University College Hospital T-cell-1 |
| University College Hospital T-cell-1 |
External Source Codes:
| NCI Thesaurus Code | C38897 (see NCI Thesaurus info) |
Other Properties:
| Name | Value | Source |
|---|---|---|
| ACTIVE | 1 | SNOMEDCT_US |
| AQL | AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR | MSH |
| CASE_SIGNIFICANCE_ID | 900000000000017005 | SNOMEDCT_US |
| CASE_SIGNIFICANCE_ID | 900000000000020002 | SNOMEDCT_US |
| CASE_SIGNIFICANCE_ID | 900000000000448009 | SNOMEDCT_US |
| Contributing_Source | CTRP | NCI |
| Contributing_Source | GDC | NCI |
| CTV3ID | X80f4 | SNOMEDCT_US |
| DC | 1 | MSH |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DID | 1556-6820 | CSP |
| DX | 19930101 | MSH |
| EFFECTIVE_TIME | 20020131 | SNOMEDCT_US |
| FX | D011948 | MSH |
| HN | 2018 (1993); use T3 ANTIGEN COMPLEX 1983-92; use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92 | MSH |
| MDA | 19920507 | MSH |
| MMR | 20170602 | MSH |
| MN | D23.050.301.264.894.095 | MSH |
| MN | D23.101.100.894.095 | MSH |
| PM | 2018; see ANTIGENS, CD3 1993-2017; CD3 COMPLEX was indexed under RECEPTORS, ANTIGEN, T-CELL 1990-92; under ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92; under ANTIGENS, SURFACE 1983-87; and under ANTIGENS 1983-84; for T3 ANTIGENS see ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92 | MSH |
| RN | 0 | MSH |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~X80f4 | SNOMEDCT_US |
| TERMUI | T051424 | MSH |
| TERMUI | T051425 | MSH |
| TERMUI | T051426 | MSH |
| TERMUI | T051427 | MSH |
| TERMUI | T051428 | MSH |
| TERMUI | T051429 | MSH |
| TERMUI | T051430 | MSH |
| TH | NLM (1993) | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0108779
