Terms & Properties

Concept Unique Identifier (CUI): C0040691

NCI Thesaurus Code: C20453  (see NCI Thesaurus info)

Semantic Type: Amino Acid, Peptide, or Protein

Semantic Type: Pharmacologic Substance

Semantic Type: Biologically Active Substance

NCIt Definition: Transforming Growth Factors are a family of extracellular signaling peptides involved in cell growth stimulation. Found in hematopoietic tissue, various TGF-beta subtypes stimulate wound healing and may inhibit lymphopoiesis and myelopoiesis. TGF-alpha binds to EGFR and stimulates endothelial cell growth.

CSP Definition: any of several proteins secreted by transformed cells and stimulating growth of normal cells; transforming growth factor alpha binds the epidermal growth factor receptor and also stimulates growth of microvascular endothelial cells; transforming growth factor beta exists as several subtypes; all occur in hematopoietic tissue, stimulate wound healing, and in vitro are antagonists of lymphopoiesis and myelopoiesis.

MSH Definition: Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.

Synonyms & Abbreviations: (see Synonym Details)

Animal growth regulators, transforming growth factors

Factor, Transforming Growth

Factors, Transforming Growth

Growth Factor, Transforming

Growth Factors, Transforming

TGF

transforming growth factors

transforming growth factor

Tumor Growth Factors

External Source Codes: 

NCI Thesaurus Code

C20453 (see NCI Thesaurus info)

Other Properties:

Name	Value	Source
AN	general or unspecified; prefer specifics	MSH
AQL	AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR	MSH
DC	1	MSH
DID	1354-9974	CSP
DX	19890101	MSH
HN	89	MSH
HN	ETOH descriptor 2000.	AOD
MDA	19880524	MSH
MMR	20150602	MSH
MN	D12.644.276.963	MSH
MN	D12.776.467.960	MSH
MN	D23.529.960	MSH
PM	89	MSH
RN	76057-06-2	MSH
TERMUI	T044926	MSH
TERMUI	T044927	MSH
TH	NLM (1989)	MSH
TH	UNK (19XX)	MSH

Additional Concept Data:  (none)

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