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Terms & Properties |
Concept Unique Identifier (CUI): C0040691
NCI Thesaurus Code: C20453 (see NCI Thesaurus info)
Semantic Type: Amino Acid, Peptide, or Protein
Semantic Type: Pharmacologic Substance
Semantic Type: Biologically Active Substance
NCIt Definition: Transforming Growth Factors are a family of extracellular signaling peptides involved in cell growth stimulation. Found in hematopoietic tissue, various TGF-beta subtypes stimulate wound healing and may inhibit lymphopoiesis and myelopoiesis. TGF-alpha binds to EGFR and stimulates endothelial cell growth.
CSP Definition: any of several proteins secreted by transformed cells and stimulating growth of normal cells; transforming growth factor alpha binds the epidermal growth factor receptor and also stimulates growth of microvascular endothelial cells; transforming growth factor beta exists as several subtypes; all occur in hematopoietic tissue, stimulate wound healing, and in vitro are antagonists of lymphopoiesis and myelopoiesis.
MSH Definition: Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.
Synonyms & Abbreviations: (see Synonym Details)
Animal growth regulators, transforming growth factors |
Factor, Transforming Growth |
Factors, Transforming Growth |
Growth Factor, Transforming |
Growth Factors, Transforming |
TGF |
transforming growth factors |
transforming growth factor |
Tumor Growth Factors |
External Source Codes:
NCI Thesaurus Code | C20453 (see NCI Thesaurus info) |
Name | Value | Source |
---|---|---|
AN | general or unspecified; prefer specifics | MSH |
AQL | AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR | MSH |
DC | 1 | MSH |
DID | 1354-9974 | CSP |
DX | 19890101 | MSH |
HN | 89 | MSH |
HN | ETOH descriptor 2000. | AOD |
MDA | 19880524 | MSH |
MMR | 20150602 | MSH |
MN | D12.644.276.963 | MSH |
MN | D12.776.467.960 | MSH |
MN | D23.529.960 | MSH |
PM | 89 | MSH |
RN | 76057-06-2 | MSH |
TERMUI | T044926 | MSH |
TERMUI | T044927 | MSH |
TH | NLM (1989) | MSH |
TH | UNK (19XX) | MSH |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0040691