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| Terms & Properties |
Note: The CUI C0030842 you searched for is obsolete.
Concept Unique Identifier (CUI): C0030842
NCI Thesaurus Code: C1500 (see NCI Thesaurus info)
Semantic Type: Organic Chemical
Semantic Type: Antibiotic
NCIt Definition: Any beta-lactam antibiotic derived from Penicillium fungi with bactericidal activity. Penicillin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
NCI-GLOSS Definition: A drug that is used to treat infection. It belongs to the family of drugs called antibiotics.
CSP Definition: group of natural or semisynthetic antibacterial antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group; they exert a bacteriocidal as well as bacteriostatic effect on susceptible bacteria by interfering with the final stages of the synthesis of cell wall peptidoglycan.
MSH Definition: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Synonyms & Abbreviations: (see Synonym Details)
| Antibiotics, Penicillin |
| Medicinal product containing penicillin and acting as antibacterial agent (product) |
| Penicillin (substance) |
| Penicillin antibacterial agent |
| Penicillin Antibiotics |
| Penicillin Antibiotic |
| Penicillin-containing product |
| Penicillins |
| penicillin |
| Product containing penicillin (product) |
External Source Codes:
| NCI Thesaurus Code | C1500 (see NCI Thesaurus info) |
Other Properties:
| Name | Value | Source |
|---|---|---|
| ACTIVE | 1 | SNOMEDCT_US |
| AQL | AD AE AG AI AN BI BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR | MSH |
| CASE_SIGNIFICANCE_ID | 900000000000448009 | SNOMEDCT_US |
| CHEBI_ID | CHEBI:17334 | NCI |
| CTV3ID | x009C | SNOMEDCT_US |
| CTV3ID | XV1z2 | SNOMEDCT_US |
| CTV3ID | XVDPT | SNOMEDCT_US |
| DC | 1 | MSH |
| DEFINITION_STATUS_ID | 900000000000073002 | SNOMEDCT_US |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DID | 0199-8025 | CSP |
| DX | 19660101 | MSH |
| EFFECTIVE_TIME | 20160131 | SNOMEDCT_US |
| EFFECTIVE_TIME | 20180731 | SNOMEDCT_US |
| EFFECTIVE_TIME | 20210131 | SNOMEDCT_US |
| HN | 75; was PENICILLIN 1963-74; /adv eff-pois-tox was PENICILLIN TOXICOLOGY 1963-65; HETACILLIN was heading 1974-84 | MSH |
| MDA | 19990101 | MSH |
| MMR | 20160531 | MSH |
| MN | D02.065.589.099.750 | MSH |
| MN | D02.886.108.750 | MSH |
| MN | D03.633.100.300.750 | MSH |
| OL | use PENICILLINS to search PENICILLIN 1966-74 & HETACILLIN 1974-84 | MSH |
| PA | D000900 | MSH |
| PM | 75; was PENICILLIN 1963-74; /adverse effects /poisoning /toxicity were PENICILLIN TOXICOLOGY 1963-65; HETACILLIN was heading 1974-84 | MSH |
| RN | 0 | MSH |
| RXAUI | 2072833 | RXNORM |
| RXCUI | 7986 | RXNORM |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~x009C | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~XV1z2 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~XVDPT | SNOMEDCT_US |
| TERMUI | T030736 | MSH |
| TERMUI | T030737 | MSH |
| TERMUI | T030738 | MSH |
| TH | NLM (1966) | MSH |
| TH | NLM (1996) | MSH |
| TH | UNK (19XX) | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0030842
