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| Terms & Properties |
Concept Unique Identifier (CUI): C0016384
NCI Thesaurus Code: C509 (see NCI Thesaurus info)
Semantic Type: Organic Chemical
Semantic Type: Pharmacologic Substance
NCIt Definition: A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)
PDQ Definition: A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI Thesaurus)
NCI-GLOSS Definition: An anticancer drug that is a type of antiandrogen.
MSH Definition: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Synonyms & Abbreviations: (see Synonym Details)
| 13311-84-7 |
| 147834 |
| 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| 215876 |
| 25378 |
| 4'-nitro-3'-trifluoromethylisobutyranilide |
| Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide |
| Apimid |
| Cebatrol |
| Chimax |
| Cytomid |
| Drogenil |
| Euflex |
| Eulexine |
| Eulexin |
| Flucinome |
| Flucinom |
| Flugerel |
| Fluken |
| Flulem |
| Fluta GRY |
| Fluta-GRY |
| Flutabene |
| Flutacan |
| FlutaGRY |
| Flutamex |
| Flutamida |
| Flutamide (substance) |
| Flutamide-containing product |
| flutamide |
| Flutamidum |
| Flutamid |
| Flutamin |
| Flutan |
| Flutaplex |
| FLUT |
| FTA |
| Fugerel |
| Grisetin |
| NFBA |
| Niftolide |
| Niftolid |
| Oncosal |
| Product containing flutamide (medicinal product) |
| Profamid |
| Propanamide, 2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)- |
| Prostacur |
| Prostadirex |
| Prostica |
| Prostogenat |
| Sch 13521 |
| SCH-13521 |
| SCH13521 |
| Tafenil |
| Tecnoflut |
| Testac |
| Testotard |
| α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide |
External Source Codes:
| NCI Thesaurus Code | C509 (see NCI Thesaurus info) |
| CAS Registry Number | 13311-84-7 (see NLM ChemIDplus info) |
| FDA UNII Code | 76W6J0943E |
| PDQ Closed Trial Search ID | 39811 |
| PDQ Open Trial Search ID | 39811 |
Other Properties:
| Name | Value | Source |
|---|---|---|
| Accepted_Therapeutic_Use_For | Hirsutism; Prostate carcinoma | NCI |
| ACTIVE | 1 | SNOMEDCT_US |
| AQL | AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR | MSH |
| CASE_SIGNIFICANCE_ID | 900000000000448009 | SNOMEDCT_US |
| CHEBI_ID | CHEBI:5132 | NCI |
| Chemical_Formula | C11H11F3N2O3 | NCI |
| Contributing_Source | CTRP | NCI |
| Contributing_Source | FDA | NCI |
| Contributing_Source | GDC | NCI |
| Contributing_Source | HemOnc | NCI |
| Contributing_Source | OORO | NCI |
| CTV3ID | he7.. | SNOMEDCT_US |
| CTV3ID | XUWyo | SNOMEDCT_US |
| DATE_LAST_MODIFIED | 2015-10-05 | PDQ |
| DC | 1 | MSH |
| DEFINITION_STATUS_ID | 900000000000073002 | SNOMEDCT_US |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DID | 0170-7665 | CSP |
| DID | 0220-6201 | CSP |
| DX | 19910101 | MSH |
| EFFECTIVE_TIME | 20030131 | SNOMEDCT_US |
| EFFECTIVE_TIME | 20180731 | SNOMEDCT_US |
| FDA_UNII_CODE | 76W6J0943E | DRUGBANK |
| HN | 91(75); was see under ANILIDES 1975-90 | MSH |
| LEVEL | Example Drugs | USPMG |
| LT | TRD | MSH |
| LT | TRD | MTH |
| LT | TRD | PDQ |
| MDA | 19741119 | MSH |
| MMR | 20160701 | MSH |
| MN | D02.065.199.420 | MSH |
| MN | D02.092.146.113.420 | MSH |
| MONOGRAPH_OFFICIAL_DATE | 05/15/1995 | USP |
| MONOGRAPH_STATUS | Official Monograph | USP |
| NCI_Drug_Dictionary_ID | 39811 | NCI |
| NCI_THESAURUS_CODE | C509 | PDQ |
| NSC_Number | 147834 | NCI |
| NSC_Number | 215876 | NCI |
| ORIG_STY | Drug/agent | PDQ |
| PA | D000726 | MSH |
| PA | D018931 | MSH |
| PID | 2488 | PDQ |
| PM | 91; was see under ANILIDES 1975-90 | MSH |
| RN | 0 | MSH |
| RN | 76W6J0943E | MSH |
| RR | 13311-84-7 (Flutamide) | MSH |
| RXAUI | 1007001 | RXNORM |
| RXAUI | 10282022 | RXNORM |
| RXAUI | 10785698 | RXNORM |
| RXAUI | 10785699 | RXNORM |
| RXAUI | 12252130 | RXNORM |
| RXAUI | 1841912 | RXNORM |
| RXAUI | 1841923 | RXNORM |
| RXAUI | 2071027 | RXNORM |
| RXAUI | 2355770 | RXNORM |
| RXAUI | 3028345 | RXNORM |
| RXAUI | 5532946 | RXNORM |
| RXAUI | 7852200 | RXNORM |
| RXAUI | 7854086 | RXNORM |
| RXAUI | 7868112 | RXNORM |
| RXAUI | 8035615 | RXNORM |
| RXAUI | 8101391 | RXNORM |
| RXAUI | 8111864 | RXNORM |
| RXAUI | 8156616 | RXNORM |
| RXAUI | 8405109 | RXNORM |
| RXAUI | 8513716 | RXNORM |
| RXAUI | 8517985 | RXNORM |
| RXAUI | 8602482 | RXNORM |
| RXAUI | 8639396 | RXNORM |
| RXAUI | 8692631 | RXNORM |
| RXAUI | 8692632 | RXNORM |
| RXAUI | 8692633 | RXNORM |
| RXCUI | 1442275 | RXNORM |
| RXCUI | 151668 | RXNORM |
| RXCUI | 153806 | RXNORM |
| RXCUI | 4508 | RXNORM |
| RXN_ACTIVATED | 01/28/2010 | RXNORM |
| RXN_ACTIVATED | 12/29/2021 | RXNORM |
| RXN_BN_CARDINALITY | single | RXNORM |
| RXN_OBSOLETED | 03/27/2013 | RXNORM |
| RXN_OBSOLETED | 05/28/2014 | RXNORM |
| RXN_OBSOLETED | 07/01/2020 | RXNORM |
| RXN_OBSOLETED | 08/30/2007 | RXNORM |
| SID | APRD00984 | DRUGBANK |
| SPL_SET_ID | 328910be-4d0e-4d7b-a062-e3ce0cf793b9 | MTHSPL |
| SPL_SET_ID | 56b6ba36-9b49-4422-a2a4-7bfa0d941a5d | MTHSPL |
| SPL_SET_ID | 82bb75cc-0d36-44ab-9ea6-2bd26998ce0f | MTHSPL |
| SPL_SET_ID | 8b5974d2-0f00-4201-a810-01320ac0cf13 | MTHSPL |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~he7.. | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~XUWyo | SNOMEDCT_US |
| TERMUI | T016690 | MSH |
| TERMUI | T016691 | MSH |
| TERMUI | T016692 | MSH |
| TERMUI | T016693 | MSH |
| TERMUI | T635253 | MSH |
| TERMUI | T635254 | MSH |
| TERMUI | T635255 | MSH |
| TERMUI | T635256 | MSH |
| TERMUI | T635259 | MSH |
| TERMUI | T635263 | MSH |
| TERMUI | T635267 | MSH |
| TERMUI | T635269 | MSH |
| TERMUI | T635277 | MSH |
| TERMUI | T635279 | MSH |
| TERMUI | T635283 | MSH |
| TERMUI | T635288 | MSH |
| TERMUI | T635290 | MSH |
| TERMUI | T635538 | MSH |
| TERMUI | T635542 | MSH |
| TERMUI | T635544 | MSH |
| TERMUI | T635546 | MSH |
| TERMUI | T635548 | MSH |
| TH | AU | MSH |
| TH | BAN (19XX) | MSH |
| TH | CA | MSH |
| TH | DE | MSH |
| TH | ES | MSH |
| TH | FDA SRS (2014) | MSH |
| TH | FR | MSH |
| TH | INN (19XX) | MSH |
| TH | MX | MSH |
| TH | NLM (1991) | MSH |
| TH | NL | MSH |
| TH | UK | MSH |
| TH | UNK (19XX) | MSH |
| TH | USAN (1975) | MSH |
| TH | USP (19XX) | MSH |
| TH | US | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0016384
